Fig. 1

POLD1 is significantly upregulated at the mRNA and protein levels in HCC compared with that in normal liver samples. A POLD1 mRNA expression in several tumor and normal controls (data were retrieved from GEPIA2)*. B Comparison of POLD1 mRNA expression in HCC (n = 369) and in normal liver samples (n = 50). C Validation of diagnostic value of POLD1 upregulation for HCC using ROC curve. Representative IHC images of POLD1 retrieved from the HPA in normal liver samples D and HCC E, scale bar 200 μm. *Each dot represents a distinct tumor (red) or normal (green) sample. The cancer names in red font indicates that POLD1 expression was upregulated in the tumor samples compared with the normal samples, the green font indicates that the expression was downregulated, and the black font indicates no significant difference between the tumor and normal samples