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Table 4 Univariate and multivariate Cox proportional risk regression analysis of factors affecting the overall survival of LUSC patients

From: Using biological information to analyze potential miRNA-mRNA regulatory networks in the plasma of patients with non-small cell lung cancer

Variables

Number of patients

Univariate

Multivariate

HR (95% CI)

p Value

HR (95% CI)

p Value

Age(y)

  ≤ 65

178

reference

   

 >65

290

1.274(0.9313–1.742)

0.13

  

Gender

 Male

350

reference

   

 Female

123

0.932(0.6665–1.304

0.682

  

Tumor stage

 stageI/II

384

reference

   

 stageIII/IV

85

0.999(0.5198–1.992)

0.9986

  

T stage

 T1/T2

383

reference

 

reference

 

 T3/T4

90

1.761(1.1188–2.773)

0.0145*

1.721(1.23–2.408)

0.0015**

N stage

 N0

297

reference

   

 N1

126

1.025(0.7169–1.466)

0.8912

  

 N2

40

1.373(0.6291–2.995)

0.4262

  

 N3

4

4.473(0.9326–21.456)

0.0611

  

 NX

6

2.342(0.7388–7.421)

   

M stage

 M0

387

reference

 

reference

 

 M1

6

3.418(1.2156–9.611)

0.0198*

3.308(1.349–8.115)

0.009**

 MX

76

1.566(1.044–2.348)

0.0301*

1.611(1.078–2.401)

0.0201*

hsa-let-7d-3p

 Low expression

236

reference

   

 High expression

237

0.873(0.6523–1.168)

0.3593

  
  1. HR Hazard ratio, CI Confifidence interval
  2. *signifificant risk factor, p < 0.05
  3. **signifificant risk factor, p < 0.01