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Table 4 Univariate and multivariate Cox proportional risk regression analysis of factors affecting the overall survival of LUSC patients

From: Using biological information to analyze potential miRNA-mRNA regulatory networks in the plasma of patients with non-small cell lung cancer

Variables Number of patients Univariate Multivariate
HR (95% CI) p Value HR (95% CI) p Value
Age(y)
  ≤ 65 178 reference    
 >65 290 1.274(0.9313–1.742) 0.13   
Gender
 Male 350 reference    
 Female 123 0.932(0.6665–1.304 0.682   
Tumor stage
 stageI/II 384 reference    
 stageIII/IV 85 0.999(0.5198–1.992) 0.9986   
T stage
 T1/T2 383 reference   reference  
 T3/T4 90 1.761(1.1188–2.773) 0.0145* 1.721(1.23–2.408) 0.0015**
N stage
 N0 297 reference    
 N1 126 1.025(0.7169–1.466) 0.8912   
 N2 40 1.373(0.6291–2.995) 0.4262   
 N3 4 4.473(0.9326–21.456) 0.0611   
 NX 6 2.342(0.7388–7.421)    
M stage
 M0 387 reference   reference  
 M1 6 3.418(1.2156–9.611) 0.0198* 3.308(1.349–8.115) 0.009**
 MX 76 1.566(1.044–2.348) 0.0301* 1.611(1.078–2.401) 0.0201*
hsa-let-7d-3p
 Low expression 236 reference    
 High expression 237 0.873(0.6523–1.168) 0.3593   
  1. HR Hazard ratio, CI Confifidence interval
  2. *signifificant risk factor, p < 0.05
  3. **signifificant risk factor, p < 0.01