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Fig. 6 | BMC Cancer

Fig. 6

From: Mammary tumors alter the fecal bacteriome and permit enteric bacterial translocation

Fig. 6

Working paradigm - Tumor-induced intestinal barrier disruption is permissive of enteric bacterial translocation. Tumors induce intestinal barrier disruption and decrease relative abundance of Lactobacillus through yet unknown mechanisms. Reduced abundance of Lactobacillus and barrier disruption allow higher enteric bacterial translocation to systemic sights including the spleen, where pro-inflammatory cytokine TNFα is reduced. These changes in intestinal physiology and immune function likely contribute to gastrointestinal and behavioral symptoms experienced by patients with cancer

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