Fig. 4
From: Mammary tumors alter the fecal bacteriome and permit enteric bacterial translocation
Mammary tumors increase splenic bacterial burden and alter splenic cytokines. Tumor mice exhibit splenomegaly that is attenuated in Resected (A). Tumor mice also have increased splenic bacterial burden as detected by FISH (B). Tumor mice also have altered splenic cytokine profiles (C). Control, Tumor, and Resected mice do not differ in the number of animals with culture-positive spleens (60, 66.7, and 66.7% respectively,chi-square likelihood ratio p = 0.96), but Tumor mice tend to have less Lactobacillus-positive spleens (D). * = p < 0.05, ** = p < 0.01, *** = p < 0.0001, NS=Not Significant, ND=Not Detected, by ANOVA and post-hoc LSD