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Table 2 PRO recovery to near baseline

From: Patient-reported outcome (PRO) results from the AGITG DOCTOR trial: a randomised phase 2 trial of tailored neoadjuvant therapy for resectable oesophageal adenocarcinoma

 

n (%) who recover to within 10 points of baseline after surgery (where QoL data available)

QoL imeasure

QoL subscale

PET responders: CF

PET non-responders randomised: DCF

PET non-responders randomised: DCF & RTT

Others

All patients

 

N

42

26

28

10

106

QLQ-C30

Physical functioning

33 (79)

18 (69)

18 (64)

10 (100)

79 (75)

Role functioning

28 (67)

19 (73)

17 (61)

6 (60)

70 (66)

Emotional functioning

37 (88)

25 (96)

25 (89)

10 (100)

97 (92)

Cognitive functioning

35 (83)

20 (77)

20 (71)

7 (70)

82 (77)

Social functioning

34 (81)

18 (69)

22 (79)

8 (80)

82 (77)

Fatigue

23 (55)

16 (62)

14 (50)

5 (50)

58 (55)

Nausea and vomiting

33 (79)

19 (73)

20 (71)

7 (70)

79 (75)

Pain

36 (86)

23 (88)

19 (68)

9 (90)

87 (82)

Dyspnoea

32 (76)

17 (65)

18 (64)

8 (80)

75 (71)

Insomnia

39 (93)

22 (85)

19 (68)

10 (100)

90 (85)

Appetite loss

36 (86)

22 (85)

25 (89)

7 (70)

90 (85)

Constipation

39 (93)

26 (100)

26 (93)

8 (80)

99 (93)

Diarrhoea

39 (93)

20 (77)

26 (93)

10 (100)

95 (90)

Financial difficulties

37 (88)

24 (92)

25 (89)

10 (100)

96 (91)

Global health status

28 (67)

18 (69)

20 (71)

8 (80)

74 (70)

Global Quality of life

30 (71)

18 (69)

18 (64)

7 (70)

73 (69)

Global health status/QoL

30 (71)

20 (77)

21 (75)

8 (80)

79 (75)

OES-18

Dysphagia

40 (95)

23 (88)

25 (89)

8 (80)

96 (91)

Problems with eating

33 (79)

26 (100)

23 (82)

9 (90)

91 (86)

Reflux

32 (76)

22 (85)

22 (79)

8 (80)

84 (79)

Pain (OES-18)

38 (90)

24 (92)

23 (82)

10 (100)

95 (90)

Trouble swallowing saliva

42 (100)

26 (100)

28 (100)

9 (90)

105 (99)

Choked when swallowing

41 (98)

25 (96)

27 (96)

10 (100)

103 (97)

Dry mouth

38 (90)

20 (77)

25 (89)

9 (90)

92 (87)

Trouble with taste

39 (93)

23 (88)

22 (79)

8 (80)

92 (87)

Trouble with coughing

36 (86)

22 (85)

21 (75)

7 (70)

86 (81)

Trouble with talking

37 (88)

23 (88)

25 (89)

9 (90)

94 (89)