Table 1 patient characteristics, including survival outcomes
Characteristic | PET responders: CF (N = 45) | PET non-responders randomised: DCF (N = 31) | PET non-responders randomised: DCF + radiation (N = 35) | Others (N = 13) | All patients (N = 124) |
|---|---|---|---|---|---|
Age in years, median (range) | 61 (42–78) | 60 (38–77) | 63 (44–76) | 65 (41–71) | 63 (38–78) |
Male | 41 (91) | 27 (87) | 32 (91) | 10 (77) | 110 (89) |
ECOG 0 | 37 (82) | 25 (81) | 27 (77) | 13 (100) | 102 (82) |
Days between start of chemotherapy and surgery, mean (SD) | 69 (10) | 117 (19) | 126 (24) | 57 (22) | |
PFS in months, Median (95% CI) | 27 (12–.) | 22 (14–27) | 22 (14–.) | 13 (5–.) | 22 (15–36) |
OS in months, Median (95% CI) | 61 (26–.) | 30 (17–55) | 35 (20–.) | 31 (5–.) | 36 (25–61) |
Baseline QLQ-C30 and QLQ-OES18 scores per scale, mean (SD) | |||||
Physical functioning | 94 (10) | 94 (12) | 96 (9) | 89 (13) | 94 (10) |
Role functioning | 88 (22) | 82 (29) | 90 (16) | 85 (20) | 87 (22) |
Emotional functioning | 76 (23) | 74 (21) | 74 (19) | 81 (16) | 75 (21) |
Cognitive functioning | 86 (17) | 91 (20) | 89 (14) | 94 (11) | 89 (16) |
Social functioning | 78 (28) | 75 (29) | 80 (23) | 79 (26) | 78 (27) |
Fatigue | 19 (20) | 24 (20) | 19 (19) | 25 (21) | 21 (20) |
Nausea and vomiting | 8 (14) | 16 (26) | 11 (14) | 12 (17) | 11 (18) |
Pain | 17 (21) | 15 (22) | 14 (16) | 26 (19) | 17 (20) |
Dyspnoea | 10 (15) | 9 (22) | 7 (18) | 8 (15) | 9 (18) |
Insomnia | 29 (33) | 22 (29) | 24 (26) | 36 (29) | 27 (30) |
Appetite loss | 17 (23) | 23 (30) | 24 (23) | 31 (29) | 22 (26) |
Constipation | 12 (22) | 14 (19) | 13 (18) | 23 (34) | 14 (22) |
Diarrhoea | 5 (14) | 5 (12) | 3 (10) | 5 (13) | 5 (12) |
Financial difficulties | 23 (24) | 26 (31) | 29 (31) | 18 (29) | 25 (28) |
Global health status/QoL | 74 (18) | 75 (15) | 72 (16) | 74 (15) | 74 (16) |
Dysphagia | 22 (23) | 27 (20) | 25 (23) | 21 (19) | 24 (22) |
Problems with eating | 27 (24) | 40 (28) | 38 (27) | 46 (31) | 35 (27) |
Reflux | 17 (18) | 23 (28) | 21 (27) | 27 (24) | 21 (24) |
Pain (OES-18) | 22 (23) | 21 (22) | 23 (21) | 23 (18) | 22 (21) |
Trouble swallowing saliva | 13 (24) | 17 (28) | 14 (28) | 15 (26) | 14 (26) |
Choked when swallowing | 9 (15) | 12 (28) | 21 (28) | 13 (22) | 14 (23) |
Dry mouth | 12 (18) | 35 (33) | 19 (30) | 13 (22) | 19 (27) |
Trouble with taste | 4 (13) | 9 (20) | 16 (28) | 10 (16) | 9 (20) |
Trouble with coughing | 9 (21) | 15 (27) | 11 (22) | 8 (15) | 11 (22) |
Trouble with talking | 3 (10) | 4 (14) | 6 (20) | 5 (13) | 4 (14) |