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Fig. 7 | BMC Cancer

Fig. 7

From: Establishment of an orthotopic prostate cancer xenograft mouse model using microscope-guided orthotopic injection of LNCaP cells into the dorsal lobe of the mouse prostate

Fig. 7

Immunohistochemistry of an orthotopic prostate tumor. a and b Tumors contained a rich network of vessels. Intratumoral vessel diameter was larger than peritumoral vessel diameter, but microvessel density was increased in the peritumoral region. c The VEGF-A protein was positively expressed. d Tumors were human-specific Ki-67 positive. e and f Tumor cells showed strong positive nuclear staining for human AR, and moderate positive cytoplasmic staining for human-specific PSA. g and h Tumor cells were p63 negative and showed diffuse P504S expression. The contralateral normal DP was diffusely positive for p63 in the basal cell layer and AR, PSA, and P504S negative. Magnification: a, b, and c × 4, d × 10, and e–g × 20

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BMC Cancer

ISSN: 1471-2407

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