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Fig. 6 | BMC Cancer

Fig. 6

From: Establishment of an orthotopic prostate cancer xenograft mouse model using microscope-guided orthotopic injection of LNCaP cells into the dorsal lobe of the mouse prostate

Fig. 6

Macroscopic and microscopic characteristics of an orthotopic prostate tumor. a The tumor (black arrow) arose from the lateral aspect of the DP; the contralateral DP was unaffected (red arrow head). b The free border of the tumor was covered with a uniform fibrous capsule. Tumor cells showed pronounced cytologic atypia with uniformly enlarged nuclei. c Acini were entrapped by a variably fibrotic stroma. d Acini had sharp, angular contours. e A considerable peritumoral inflammatory infiltrate containing neutrophils and macrophages was present. f The intratumoral region displayed gross hemorrhage, substantial necrosis and remnant islands of tumor cells. g The intratumoral region was infiltrated by neutrophils. h Haphazardly arranged microacinar structures were lined by high columnar tumor cells (white arrow). i The peritumoral and regional lymph nodes showed pronounced inflammation. SV, Seminal vesicle; BL, bladder; R, rectum; T, testis; A, artery; V, vein; DP, dorsal prostate lobes; Magnification: I × 4, C, D, and F × 10, and B, E, G, and H × 20

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