Fig. 4

Differentially expressed transcript profile of cervical cancer exosomes. A Distinct mRNA expression profiles in HPV-positive vs. HPV-negative and HPV16-positive vs HPV18-positive. The inclusion criteria of these transcripts was a 2-fold difference of log2 (fold-change) in either direction with a p value <0.05. Red signal, represents higher relative expression as compared to green signal. B Quantitative Venn diagram showing differentially expressed gene. C Volcano plot showing overall clustering of differentially expressed exosomal transcripts in HPV-positive vs. HPV-negative and HPV16-positive vs. HPV18-positive (left panels). Volcano plot showing distinct clustering of top 20 transcripts (right panels). Blue color indicates log2 fold change ≥1.5 and p value ≤0.05. Red dots indicate absolute log2 fold change ≥1.5 and FDR/adjusted p value ≤0.05. Gray lines indicate the marginal lines separating DEGs from non-DEGs, with the horizontal lines denoting the p value threshold (p ≤ 0.05) and vertical lines the fold change cut off (≥ 1.5 or < 0.67).