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Table 3 Multivariate Cox regression of factors influencing breast cancer-free survival in patients with PABC and non-PABC

From: Clinical characteristics, pregnancy outcomes and ovarian function of pregnancy-associated breast cancer patients: a retrospective age-matched study

Variable

level

Event

Total

Univariate mode

Multivariate model

HR

95%CI

P

HR

95%CI

P

PABC

Yes

16

63

2.340

1.164 ~ 4.701

0.017

0.971

0.437 ~ 2.158

0.943

No

16

126

1

     

Age at

diagnosis

 ≤ 35

23

133

1.125

0.520 ~ 2.437

0.765

   

 > 35

9

56

1

     

Family

history

Yes

6

18

2.430

0.997 ~ 5.925

0.051

2.204

0.831 ~ 5.844

0.112

No

26

171

1

     

TNM stage

III/IV

25

48

16.943

7.262 ~ 39.528

 < 0.001

16.017

5.830 ~  ~ 44.006

 < 0.001

0/I/II

7

141

1

     

ER

 + 

19

120

0.723

0.357 ~ 1.464

0.367

   

-

13

69

1

     

PR

 + 

14

108

0.506

0.251 ~ 1.020

0.057

0.639

0.275 ~ 1.489

0.300

-

18

81

1

     

HR

 + 

19

124

0.652

0.322 ~ 1.321

0.235

   

-

13

65

1

     

Her-2

 + 

25

120

2.261

0.976 ~ 5.234

0.057

1.568

0.652 ~ 3.774

0.315

_

7

78

1

     

Ki-67

 ≥ 14%

27

149

1.905

0.730 ~ 4.972

0.188

0.880

0.305 ~ 2.537

0.813

 < 14%

5

40

1

     

Breast surgery

BMS

27

156

1.347

0.515 ~ 3.522

0.543

   

CMS

5

33

      

Chemotherapy

No

1

9

1

     

ACT

17

142

0.844

0.112 ~ 6.363

0.870

   

NACT + ACT

14

38

4.177

0.545 ~ 32.002

0.209

   

Radiotherapy

Yes

27

101

5.332

2.051 ~ 13.862

0.001

2.186

0.766 ~ 6.240

0.144

No

5

88

1

     

Endocrine therapy

Yes

10

106

0.278

0.131 ~ 0.588

0.001

0.254

0.099 ~ 0.653

0.004

No

22

83

1

     

Targeted therapy

Yes

5

46

0.643

0.247 ~ 1.673

0.366

   

No

27

143

1

    Â