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Fig. 3 | BMC Cancer

Fig. 3

From: Ovarian cancer G protein-coupled receptor 1 inhibits A549 cells migration through casein kinase 2α intronless gene and neutral endopeptidase

Fig. 3

OGR1 inhibits A549 cell migration via CK2α: A OGR1 inhibits A549 cell migration, but the presence of CK2 inhibitor, CX4945, abrogated the effect of OGR1 but not the presence of NEP inhibitor, thiorphan (THP). A549 cells were transfected with pDNA3.1-OGR1 or pcDNA3.1 (Vector) in the presence of CK2 and NEP inhibitors. Cell migration was analyzed, and the image was taken hourly. B To measure the area of the wound, the length of scratches was measured on the light microscope and plotted on the graph. The wound area of control 0 h was taken as 100%, and the red line in Fig. 3A indicates the scale of 100 µm. Error bars represent the Mean ± SD of three independent experiments. The p-value of statistical significance was set as p < 0.05 (*) or 0.01 (**)

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