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Table 2 The association between continuity use of lipid-lowering therapy and GI cancer

From: Lipid-lowering drug adherence and combination therapy effects on gastrointestinal cancer in patients with dyslipidemia without diabetes: a retrospective cohort study in South Korea

 

Gastrointestinal cancer

HR

95% CI

Adherence to lipid-lowering therapy

 non-user

Ref

 MPR < 25%

1.029

0.835

1.268

 MPR < 50%

0.741

0.574

0.958

 MPR < 75%

0.636

0.480

0.842

 MPR ≥ 75%

0.438

0.305

0.629

Drug adherence (MPR, %)

 Aspirin

0.995

0.991

0.998

 Metformin

0.996

0.980

1.012

Primary medical institution for treatment of dyslipidemia

 Community health center

0.752

0.468

1.209

 clinic

0.711

0.506

0.999

 Hospital

0.868

0.573

1.314

 General hospital

0.766

0.523

1.121

 Tertiary hospital

Ref

CCI

1.193

1.127

1.263

Sex

 Male

1.874

1.582

2.219

 Female

Ref

Age

 30–44

Ref

 45–59

2.612

1.906

3.579

 60–75

5.656

4.000

7.998

BMI

  < 18.5

1.009

0.496

2.051

 18.5–22.9

Ref

 23–24.9

1.036

0.844

1.272

 25–29.9

0.888

0.723

1.091

 ≥ 30

0.953

0.578

1.571

Residual area

 Capital area

1.121

0.924

1.360

 Metropolitan

0.937

0.749

1.172

 Other

Ref

Income

 Low

1.085

0.857

1.373

 Low-moderate

1.049

0.838

1.313

 Moderate-high

1.073

0.856

1.344

 High

Ref

Insurance

 Medicaid

1.410

0.832

2.391

 Self-Employed

1.107

0.932

1.315

 Employees

Ref

Year of diagnosis

 2004–2007

Ref

 2008–2011

0.688

0.556

0.851

 2012–2015

0.631

0.458

0.867

  1. MPR medication possession ratio, CCI Charlson Comorbidity Index, HR Hazard Ratio, 95% CI 95% confidence interval