Decreased serum apolipoprotein A1 level predicts poor prognosis of patients with de novo myelodysplastic syndromes

Table 2 Univariate and multivariate analyses of different prognostic parameters for overall survival of 228 patients with MDS

Variables	Univariate analysis for OS		Multivariate analysis for OS
Variables	*P-value*	95%CI	*P-value*	HR	95%CI
Age ≥ 60(years)	< 0.0001	12.429–21.571	< 0.0001	2.679	1.697–4.232
Gender (male)	0.012	14.393–27.607	0.059	1.542	0.984–2.417
HB < 10 g/dl	0.005	15.478–28.522	0.101	0.647	0.384–1.089
NE < 0.8 × 10⁹/L	0.101	10.024–27.976	0.885	1.035	0.653–1.639
PLT < 100 × 10⁹/L	0.121	12.288–35.712	0.204	0.707	0.414–1.208
BM blast > 5%	< 0.0001	9.280–18.720	< 0.0001	3.160	2.033–4.912
IPSS-R cytogenetic risk group	0.012	23.159–48.841	0.005	1.346	1.091–1.660
IPSS-R score	< 0.0001	23.159–48.841	–	–	–
With cardiovascular comorbidity	0.710	12.434–61.566	–	–	–
HDL ≤ 0.91 mmol/L	0.002	12.286–25.714	0.584	1.175	0.659–2.093
ApoA1 ≤ 1.02 g/L	< 0.0001	12.486–25.514	0.034	1.847	1.047–3.258

Abbreviations: HB hemoglobin, NE neutrophil, PLT platelet, BM bone marrow, IPSS-R Revised International Prognostic Scoring System, HDL high-density lipoprotein, ApoA1 apolipoprotein A1

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