| Uncommon (N = 74) | 19del (N = 530) | L858R (N = 477) | p-value |
---|---|---|---|---|
Sex | Â | Â | Â | 0.38 |
 female | 41(55.4%) | 304(57.4%) | 292(61.2%) |  |
 male | 33(44.6%) | 226(42.6%) | 185(38.8%) |  |
Age, years | Â | Â | Â | 0.07 |
  ≤ 60 | 25(33.8%) | 228(43.0%) | 175(36.7%) |  |
  > 60 | 49(66.2%) | 302(57.0%) | 302(60.4%) |  |
KPS | Â | Â | Â | 0.11 |
 90-100 | 66(89.2%) | 411(77.5%) | 391(82.0%) |  |
 70-89 | 7(9.5%) | 102(19.2%) | 71(14.9%) |  |
  ≤ 70 | 1(1.4%) | 17(3.2%) | 15(3.1%) |  |
Lung M | Â | Â | Â | 0.18 |
 no | 31(41.9%) | 233(44.0%) | 235(49.3%) |  |
 yes | 43(58.1%) | 297(56.0%) | 242(50.7%) |  |
Adrenal gland M | Â | Â | Â | 0.56 |
 no | 72(97.3%) | 503(94.9%) | 450(94.3%) |  |
 yes | 2(2.7%) | 27(5.1%) | 27(5.7%) |  |
Liver M | Â | Â | Â | 0.90 |
 no | 68(91.9%) | 494(93.2%) | 445(93.3%) |  |
 yes | 6(8.1%) | 36(6.8%) | 32(6.7%) |  |
Brain M | Â | Â | Â | 0.51 |
 no | 51(68.9%) | 382(72.1%) | 355(74.4%) |  |
 yes | 23(31.1%) | 148(27.9%) | 122(25.6%) |  |
Distant LN M | Â | Â | Â | 0.27 |
 no | 41(55.4%) | 259(48.9%) | 255(53.5%) |  |
 yes | 33(44.6%) | 271(51.1%) | 222(46.5%) |  |
Bone M | Â | Â | Â | 0.02 |
 no | 51(68.9%) | 298(56.2%) | 248(52.0%) |  |
 yes | 23(31.1%) | 232(43.8%) | 229(48.0%) |  |
Oligo-M | Â | Â | Â | 0.43 |
 no | 64(86.5%) | 445(84.0%) | 389(81.6%) |  |
 yes | 10(13.7%) | 84(16.0%) | 88(18.4%) |  |
TKI generations |  |  |  | < 0.001 |
 1st | 45(60.8%) | 476(89.8%) | 409(85.7%) |  |
 2nd | 16(21.6%) | 20(3.8%) | 16(3.4%) |  |
 3rd | 13(17.6%) | 34(6.4%) | 52(10.9%) |  |