Fig. 3
From: Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes
Relative telomere length dynamics and BCR signaling activity. Prior clonal evolution, RTL was A) lower in CLL samples with less phosphorylated ERK1/2 (Pearson r = 0.63; P = 0.04) and B) less phosphorylated ZAP-70/SYK (Pearson r = 0.60; P = 0.05). In later stages, RTL was C) lower in CLL cases with less phosphorylated ERK1/2 (Pearson r = 0.66; P = 0.04), D) less phosphorylated ZAP-70/SYK (Pearson r = 0.79; P = 0.01), and E) less phosphorylated NFkB (Pearson r = 0.70; P = 0.02)