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Fig. 2 | BMC Cancer

Fig. 2

From: Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes

Fig. 2

Examples of RTL change associated with shifts in a proportion of clones bearing different aberrations. A) In the patient pt1, the RTL increased in disease relapse (the follow-up sample collected 81 months after the baseline sample, arrows indicate each sampling). The proportion of a new clone bearing del(11q), del(8p), del(15p), and a TP53 mutation increased to approximately 40% of the CLL population in the follow-up sample. At the same time, the proportion of the clone with sole del(11q) shrunk to approximately 35% of the CLL population and the clone with del(13q) disappeared. Concurrently with these changes of clonal proportions, higher RTL was detected. B) In the patient pt2 studied in three time points with three distinct clones carrying different TP53 mutations, telomeres initially lengthened and subsequently shortened, closely following an exchange of a dominating TP53 mutation (the first follow-up sample was collected 27 months after the baseline sample and the second follow-up sample was collected 10 months later, arrows indicate each sampling)

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