Fig. 1

Relative telomere length dynamics in the context of TP53 mutation clonal evolution. A) The analysis of the RTL and TP53 mutation status (the cut-off VAF 10%) within the basic CLL cohort (n = 198), showing a difference between the subgroups of patients characterized by wtTP53 (blue; n = 135), patients expanding mutTP53 above 10% VAF later in a disease course (yellow; n = 23), and mutTP53 (red; n = 40). B) RTLs in baseline and follow-up samples in the evolTP53 cohort (n = 26; Wilcoxon signed rank P = 0.291) C) RTL change in individual patients in the evolTP53 cohort. Telomeres became shorter in 10/26 (38.5%), remained stable in 10/26 (38.5%), or became longer in 6/26 (23.1%) patients. Higher RTL shrank and lower RTL extended with an inverse relationship during the disease course (Pearson r = -0.75, P < 0.001). RTL change marks: ▼shortening, ○ stable, ▲ prolonging. The cut-off value for RTL change was set to 5% difference of RTL between baseline and follow-up samples