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Table 2 Annotation of proteins deregulated after GnRH agonist treatment for (A) their molecular functions, biological processes and cellular components and (B) Reactome Pathways using STRING database

From: Quantitative proteomic analysis of GnRH agonist treated GBM cell line LN229 revealed regulatory proteins inhibiting cancer cell proliferation

(A) Molecular functions, biological processes and cellular components

Biological Process (GO)

S. No.

GO-term

Description

Count in gene set

False discovery rate

1

GO:0032101

Regulation of response to external stimulus

11 of 955

0.00033

2

GO:0050727

Regulation of inflammatory response

7 of 338

0.00085

3

GO:0031347

Regulation of defense response

9 of 676

0.00085

4

GO:0080134

Regulation of response to stress

11 of 1299

0.001

5

GO:0010951

Negative regulation of endopeptidase activity

6 of 242

0.001

Molecular Function (GO)

S. No.

GO-term

Description

Count in gene set

False discovery rate

1

GO:0004866

Endopeptidase inhibitor activity

6 of 169

0.0000413

2

GO:0004857

Enzyme inhibitor activity

8 of 388

0.0000413

3

GO:0030234

Enzyme regulator activity

9 of 1016

0.001

4

GO:0098772

Molecular function regulator

11 of 1793

0.0027

5

GO:0004869

Cysteine-type endopeptidase inhibitor activity

3 of 57

0.0037

Cellular Component (GO)

S. No.

GO-term

Description

Count in gene set

False discovery rate

1

GO:0031983

Vesicle lumen

8 of 341

0.0000152

2

GO:0034774

Secretory granule lumen

7 of 323

0.000095

3

GO:0005576

Extracellular region

15 of 2505

0.00015

4

GO:0005788

Endoplasmic reticulum lumen

6 of 299

0.00039

5

GO:0005615

Extracellular space

9 of 1134

0.0023

(B) PATHWAYS

S. No.

Pathway

Description

Count in gene set

False discovery rate

1

HSA-381426

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

2 of 38

0.031

2

HSA-109582

Hemostasis

5 of 591

0.031