Table 3 Comparative results of genotypic frequencies of selected polymorphisms in cases and controls and the association with glioblastoma risk. Significant P-values are represented in bold
From: Polymorphisms in autophagy genes are genetic susceptibility factors in glioblastoma development
SNP | Inheritance model | Genotype | Patients N (%) | Controls N (%) | p-value | OR (IC 95%) |
|---|---|---|---|---|---|---|
ATG2B rs3759601 | Codominant | CC | 55 (31.6%) | 39 (14.8%) | 0.000 | 1 |
CG | 73 (42%) | 115 (43.6%) | 0.433 (0.259–0.721) | |||
GG | 46 (26.4%) | 110 (41.7%) | 0.284 (0.165–0.488) | |||
Recessive | CC + CG | 18 (73.6%) | 154 (78.3%) | 0.001 | 1 | |
GG | 46 (26.4%) | 110 (41.7%) | / | 0.645 (0.409–1.018) | ||
Dominant | CC | 55 (31.6%) | 39 (14.8%) | 0.000 | 1 | |
CG + GG | 119 (68.4%) | 225 (85.2%) | / | 0.442 (0.266–0.735) | ||
ATG5 rs2245214 | Codominant | CC | 67 (38.5%) | 106 (40.2%) | 0.926 | |
CG | 85 (38.9%) | 127 (48.1%) | ||||
GG | 22 (12.6%) | 31 (11.7%) | ||||
Recessive | CC + CG | 152 (87.4%) | 223 (88.3%) | 0.777 | ||
GG | 22 (12.6%) | 31 (11.7%) | / | |||
Dominant | CC | 67 (38.5%) | 106 (40.2%) | 0.730 | ||
CG + GG | 107 (61.5%) | 158 (59.8%) | / | |||
ATG10 rs1864183 | Codominant | CC | 32 (18.4%) | 68 (25.8%) | 0.030 | 1 |
CT | 96 (55.2%) | 151 (57.2%) | 1.379 (0.831–2.290) | |||
TT | 46 (26.4%) | 45 (17%) | 2.350 (1.282–4.307) | |||
Recessive | CC + CT | 128 (73.6%) | 219 (83%) | 0.018 | 1 | |
TT | 46 (26.4%) | 45 (17%) | / | 1.863 (1.154–3.006) | ||
Dominant | CC | 32 (18.4%) | 68 (25.8%) | 0.072 | ||
CT + TT | 142 (81.6%) | 196 (74.2%) | / | |||
ATG16L1 rs2241880 | Codominant | GG | 45 (25.9%) | 63 (23.9%) | 0.784 | |
GA | 92 (52.9%) | 138 (52.3%) | ||||
AA | 37 (21.3%) | 63 (23.9%) | ||||
Recessive | GG + GA | 137 (78.7%) | 201 (76.1%) | 0.526 | ||
AA | 37 (21.3%) | 63 (23.9%) | / | |||
Dominant | GG | 45 (25.9%) | 63 (23.9%) | 0.635 | ||
GA + AA | 129 (74.1%) | 201(76.1%) | / | |||
NOD2 rs2066844 | Codominant | CC | 135 (77.6%) | 167 (88.4%) | 0.018 | 1 |
CT | 35 (20.1%) | 21 (11.1%) | 2.062 (1.147–3.707) | |||
TT | 4 (2.3%) | 1 (0.5%) | 4.948 (0.547–44.79) | |||
Recessive | CC + CT | 170 (97.7%) | 188 (99.5%) | 0.148 | ||
TT | 4 (2.3%) | 1 (0.5%) | / | |||
Dominant | CC | 135 (77.6%) | 167 (88.4%) | 0.006 | 1 | |
CT + TT | 39 (22.4%) | 22 (11.6%) | / | 2.193 (1.241–3.877) | ||
NOD2 rs2066845 | Codominant | GG | 168 (96.6%) | 100 (99%) | 0.212 | |
GC | 6 (3.4%) | 1 (1%) | ||||
CC | - | - | ||||
Recessive | GG + GC | 174 (100%) | 101 (100%) | - | ||
CC | - | - | / | |||
Dominant | GG | 168 (96.6%) | 100 (99%) | 0.212 | ||
GC + CC | 6 (3.4%) | 1 (1%) | / |