| |
Exposure
|
Outcome
|
|---|
|
Factors
|
Total (n = 256)
|
ATB (-) Group (n = 210)
|
ATB ( +) Group (n = 46)
|
P-value
|
CR & PR (n = 71)
|
SD & PD (n = 185)
|
P-value
|
|---|
|
Age (Years) Mean [SD]
|
65.5 [9.5]
|
65.5 [9.6]
|
65.3 [9.4]
|
0.942
|
66.5 [9.7]
|
65.1 [9.4]
|
0.400
|
|
Ethnicity- No. (%)
|
|
Non-Hispanic
|
243 (94.9)
|
200 (95.2) 10
|
43 (93.5) 3
|
0.903
|
69 (97.2) 2
|
174 (94.1)
| |
|
Hispanic/Latino
|
13 (5.1)
|
(4.8)
|
(6.5)
| |
(2.8)
|
11 (5.9)
|
0.482
|
|
Pack Years
|
|
Mean [SD]
|
32.9 [25.9]
|
33.8 [26.3]
|
29.2 [23.9]
|
0.435
|
30.5 [23.9]
|
33.8 [26.6]
|
0.496
|
|
Clinical Stage- No. (%)
|
|
Stage 3
|
16 (6.2)
|
14 (6.7)
|
2 (4.3)
|
0.801
|
5 (7.0)
|
11 (5.9)
|
0.971
|
|
Stage 4
|
240 (93.8)
|
196 (93.3)
|
44 (95.7)
| |
66 (93.0)
|
174 (94.1)
| |
|
Race- No. (%)
|
|
White
|
241 (94.2)
|
200 (95.2)
|
41 (89.1)
| |
65 (91.5)
|
176 (95.1)
| |
|
Black or African American
|
9 (3.5)
|
7(3.3)
|
2 (4.3)
|
0.109
|
3 (4.2)
|
6 (3.2)
|
0.429
|
|
Asian
|
6 (2.3)
|
3(1.4)
|
3 (6.5)
| |
3 (4.2)
|
3 (1.6)
| |
|
Gender- No. (%)
|
|
Female
|
120 (47.0)
|
98 (46.7)
|
22 (47.8)
|
1.000
|
29 (40.8)
|
91 (49.2) 94
|
0.290
|
|
Male
|
136 (53.0)
|
112 (53.3)
|
24 (52.2)
| |
42 (59.2)
|
(50.8)
| |
|
Smoking Status- No. (%)
|
|
Never
|
38 (14.8)
|
29 (13.8)
|
9 (19.6)
| |
10 (14.1)
|
28 (15.1)
| |
|
Former
|
184 (71.9)
|
153 (72.9)
|
31 (67.4)
|
0.606
|
51 (71.8)
|
133 (71.9)
|
0.958
|
|
Current
|
34 (13.3)
|
28 (13.3)
|
6 (13.0)
| |
10 (14.1)
|
24 (13.0)
| |
|
Marital Status- No. (%)
|
|
Single
|
23 (9.0)
|
19 (9.0)
|
4 (8.7)
| |
10 (14.1)
|
13 (7.0)
| |
|
Married/Cohabitating
|
156 (60.9)
|
133 (63.3)
|
23 (50.0)
|
0.601
|
40 (56.3)
|
116 (62.7)
|
0.185
|
|
Widowed/Divorced/Separated
|
48 (18.8)
|
38 (18.1)
|
10 (21.7)
| |
12 (16.9)
|
36 (19.5)
| |
|
Not Reported
|
29 (11.3)
|
20 (9.6)
|
9 (19.6)
| |
9 (12.7)
|
20 (10.8)
| |
|
Prior Surgery- No. (%)
|
|
No
|
203 (79.3)
|
162 (77.1)
|
41 (89.1)
|
0.106
|
59 (83.1)
|
144 (77.8)
|
0.449
|
|
Yes
|
53 (20.7)
|
48 (22.9)
|
5 (10.9)
| |
12 (16.9)
|
41 (22.2)
| |
|
Prior Chemotherapy- No. (%)
|
|
No
|
110 (43.0)
|
92 (43.8)
|
18 (39.1)
|
0.677
|
41 (57.7)
|
69 (37.3)
|
0.005*
|
|
Yes
|
146 (57.0)
|
118 (56.2)
|
28 (60.9)
| |
30 (42.3)
|
116 (62.7)
| |
|
Prior Radiation- No. (%)
|
|
No
|
178 (69.5)
|
148 (70.5)
|
30 (65.2)
|
0.600
|
50 (70.4)
|
128 (69.2)
|
0.968
|
|
Yes
|
78 (30.5)
|
62 (29.5)
|
16 (34.8)
| |
21 (29.6)
|
57 (30.8)
| |
|
Prior Targeted Therapy- No. (%)
|
|
No
|
215 (84.0)
|
173 (82.4)
|
42 (91.3)
|
0.203
|
64 (90.1)
|
151 (81.6)
|
0.141
|
|
Yes
|
41 (16.0)
|
37 (17.6)
|
4 (8.7)
| |
7 (9.9)
|
34 (18.4)
| |
|
Histology- No. (%)
|
|
Adenocarcinoma
|
147 (57.4)
|
119 (56.7)
|
28 (60.9)
| |
43 (60.6)
|
104 (56.2)
| |
|
Squamous Cell Carcinoma
|
59 (23.0)
|
49 (23.3)
|
10 (21.7)
|
0.865
|
15 (21.1)
|
44 (23.8)
|
0.818
|
|
Other NSCLC
|
50 (19.6)
|
42 (20.0)
|
8 (17.4)
| |
13 (18.3)
|
37 (20.0)
| |
|
NSAID Use- No. (%)
|
|
No
|
235 (91.8)
|
190 (90.5)
|
45 (97.8)
|
0.177
|
63 (88.7)
|
172 (93.0)
|
0.394
|
|
Yes
|
21 (8.2)
|
20 (9.5)
|
1 (2.2)
| |
8 (11.3)
|
13 (7.0)
| |
|
PPI Use- No. (%)
|
|
No
|
195 (76.2)
|
153 (72.9)
|
42 (91.3)
|
0.014*
|
50 (70.4)
|
145 (78.4)
|
0.241
|
|
Yes
|
61 (23.8)
|
57 (27.1)
|
4 (8.7)
| |
21 (29.6)
|
40 (21.6)
| |
|
ECOG- No. (%)
|
|
0
|
57 (22.3)
|
50 (23.8)
|
7 (15.2)
| |
18 (25.4)
|
39 (21.1)
| |
|
1
|
192 (75.0)
|
153 (72.9)
|
39 (84.8)
|
0.195
|
52 (73.2)
|
140 (75.7)
|
0.662
|
|
2
|
6 (2.3)
|
6 (2.9)
|
0 (0.0)
| |
1 (1.4)
|
5 (2.7)
| |
|
Not Reported
|
1 (0.4)
|
1 (0.4)
|
0 (0.0)
| |
0 (0.0)
|
1 (0.5)
| |
|
Charlson Comorbidity Index
|
|
Mean [SD]
|
6.9 [1.6]
|
6.9 [1.6]
|
6.9 [1.5]
|
0.766
|
7.1 [1.7]
|
6.9 [1.5]
|
0.528
|
- *Statistically Significant, when p < 0.05; Age, Pack Years, ECOG, and CCI (Wilcoxon Rank Sum Test); Other Variables (Chi-Square Analysis). Smoking variables not necessarily obtained at treatment start (electronic new patient questionnaire). N/A Not Applicable, ATB antibiotic, PPI Proton pump inhibitors, NSAID Non-steroidal anti-inflammatory drugs, CR Complete response, PR: Partial response, PD Progressive disease, SD Stable disease
