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Table 1 Patient characteristics in relation to preoperative blood parameters

From: Fibrinogen/albumin ratio as a promising predictor of platinum response and survival in ovarian clear cell carcinoma

Characteristic

Na (%)

CA125b (U/ml)

HE4 b

ALBb

(g/l)

FIB b (g/l)

FAR b (%)

DDI b

(pmol/L)

(mg/l)

All cases

114

186.1 (6.5–5000*)

106.2 (37.0–1500*)

41.1 (25.9–52.1)

4.58 (1.94–8.94)

10.7 (4.8–25.1)

1.5 (0.1–55.2)

Age (year)

 < 40

12 (10.5)

254.7 (66.2–912.8)

111.1 (35.5–209.6)

42.2 (33.7–49.2)

4.85 (2.69–6.59)

11.4 (6.5–16.3)

2.1 (0.7–10.7)

 40 ~ 59

75 (65.8)

131.0 (6.5–2854.0)

106.2 (37.0–1500*)

41.5 (28.1–52.1)

4.34 (1.94–8.94)

10.2 (4.9–25.1)

1.4 (0.1–55.2)

 ≥60

27 (23.7)

239.1 (13.29–5000*)

124.3 (55.5–1500*)

40.3 (25.9–46.5)

4.38 (2.42–8.79)

12.1 (6.2–23.3)

2.3 (0.2–30.6)

 P value

 

0.081

0.228

0.377

0.778

0.074

0.451

FIGO stage

 I

53 (46.5)

66.2 (6.5–5000*)

106.2 (37.0–1500*)

42.1 (28.1–52.1)

3.90 (1.94–7.15)

8.9 (4.9–21.6)

0.7 (0.1–42.6)

 II

13 (11.4)

133.5 (22.2–1401.0)

106.2 (47.0–252.4)

43.7 (31.5–47.8)

4.04 (2.30–7.92)

9.1 (5.2–25.1)

1.3 (0.3–55.2)

 III

35 (30.7)

283.8 (46.1–2854.0)

106.2 (47.4–1500*)

40.3 (30.8–46.5)

4.83 (2.20–8.94)

12.0 (5.4–23.3)

3.2 (0.5–11.0)

 IV

13 (11.4)

304.8 (48.9–5000*)

106.2 (44.1–331.9)

39.2 (25.9–49.2)

4.75 (3.42–7.95)

15.1 (8.8–11.5)

3.9 (0.6–9.2)

 P value

 

0.006

0.837

0.018

0.180

0.007

0.008

Residual tumour

 0

89 (78.1)

126.0 (6.5–5000*)

106.2 (37.0–1500*)

41.7 (28.1–52.1)

4.13 (1.94–8.94)

9.9 (4.9–25.1)

1.2 (0.1–55.2)

 ≤1 cm

16 (14.0)

551.9 (46.1–1845.3)

112.7 (68.9–904.0)

39.0 (29.0–45.4)

4.98 (3.25–8.79)

12.9 (7.3–15.9)

3.9 (0.7–9.3)

 > 1 cm

9 (7.9)

475.1 (151.6–1866.0)

209.6 (47.4–1500*)

39.2 (25.9–49.2)

5.46 (3.42–7.95)

15.3 (8.9–20.3)

5.0 (0.8–11.0)

 P value

 

0.034

0.238

0.056

0.028

< 0.001

0.009

Endometriosis

 Present

33 (28.9)

121.0 (22.2–5000*)

99.5 (44.1–1500*)

41.6 (35.7–52.1)

3.83 (2.20–7.15)

8.4 (5.0–20.0)

1.3 (0.2–42.6)

 Absent

81 (70.1)

195.0 (6.5–5000)

106.2 (37.0–1500*)

40.7 (25.9–49.9)

4.72 (1.94–8.94)

11.5 (5.0–25.0)

2.1 (0.1–55.2)

 P value

 

0.314

0.111

0.090

0.022

0.010

0.593

Platinum response

 Sensitive

85 (74.6)

105.5 (6.5–5000*)

106.2 (37.0–1500*)

41.7 (28.1–52.1)

4.00 (1.94–8.94)

9.2 (4.9–25.1)

1.0 (0.1–30.6)

 resistant

29 (25.4)

378.2 (69.93–1866.0)

134.3 (47.0–1500*)

39.2 (25.9–49.2)

4.99 (2.71–8.79)

13.3 (6.2–23.3)

5.0 (0.6–55.2)

 P value

 

0.002

0.028

0.005

0.002

0.001

< 0.001

  1. Abbreviations: ALB albumin, FIB fibrinogen, FAR fibrinogen/ albumin ratio, DDI d-dimer
  2. a Categorical data are shown in absolute value and proportion
  3. b Continuous variables are represented by median and range
  4. * The upper limit of CA125 detection is 5000. The upper limit of HE4 detection is 1500
  5. P values with statistical significance were denoted
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