Lympho-vascular invasion impacts the prognosis in breast-conserving surgery: a systematic review and meta-analysis

Table 1 The characteristic of each involved study

Study	Year	Country or Region	Study type	Number of patients	Median follow-up months	Subtype	Chemotherapy^a	Radiotherapy^b	Outcomes^c
Magee B [37]	1996	United Kingdom	Prospective	708	96	Not mentioned	No	Mixed	BR (LR)
Dinshaw KA [25]	2005	India	Retrospective	1022	53	All	Adjuvant	Yes	OS/DFS/LRR/DM/LR
Yoshida T [38]	2009	Japan	Retrospective	2243	64.7	All	Adjuvant	Mixed	DM
Yi O.V. [39]	2009	Korea	Retrospective	578	54.1	All	Mixed	Yes	LR
Lupe K [40]	2011	Canada	Retrospective	2264	62.4	All	Not mentioned	Yes	LR
Adkins FC [41]	2011	America	Retrospective	1325	62	TNBC	Adjuvant	Mixed	LRR
Freedman GM [42]	2012	Brazil	Prospective	1478	68	All	Mixed	Yes	OS
Mittendorf EA [43]	2013	America	Prospective	2983	94.8	All	Mixed	Yes	LRR
Perez CA [44]	2013	America	Retrospective	704	51	TNBC	Adjuvant	Mixed	OS/LRR/DM
Matsuda N [45]	2014	Japan	Retrospective	622	51	All	Neoadjuvant	Yes	LRR
Park JS [46]	2015	Korea	Retrospective	1071	114	All	Adjuvant	Mixed	DFS/BCSS (DSS)
Sopik V[47]	2015	Canada	Retrospective	1675	157.2	All	Mixed	Mixed	BCSS (DSS)/LR
Nichol AM[26]	2017	Canada	Retrospective	1034	151.2	HR +	Not mentioned	Half patients received	OS/EFS
Lee BM[27]	2018	Korea	Retrospective	2206	73	All	Mixed	Yes	OS
Chen SY[28]	2018	China	Retrospective	1791	50.4	All	Adjuvant	Yes	OS/DFS/LRR/DM

LR, Local recurrence; LRR, Local–regional recurrence; BR, Breast recurrence; DFS, Disease-free survival; BCSS, Breast cancer-specific survival; DSS, Disease-specific survival; DM, Distant metastases; OS, Overall survival; EFS, Event-free survival
^a Chemotherapy is according to standard therapy, "Adjuvant" represents the study that excludes the patients who received neoadjuvant chemotherapy, "Neoadjuvant" means the study only includes the patients who received neoadjuvant chemotherapy, "Mixed" means the study contains all the BCS patients. Notice: "Adjuvant" and "Mixed" contain the patients who didn't receive the chemotherapy
^b "Yes" for the radiotherapy represents that the study excludes the patients who didn't receive the radiotherapy or received the nonstandard radiotherapy, "Mixed" means the study contains all the BCS patients
^c According to the original articles, BR is equal to LR, BCSS is equal to DSS. Univariate analysis has been excluded

ISSN: 1471-2407