AAT genotype and risk of LC among women never-smokers | AAT genotype and risk of LC among men never-smokers | |||||||
---|---|---|---|---|---|---|---|---|
Variable | Cases, n (%) | Controls, n(%) | Adjusted ORa (95% CI) | Adjusted ORb (95% CI) | Cases, n (%) | Controls, n(%) | Adjusted ORa (95% CI) | Adjusted ORb (95% CI) |
Alpha-1 antitrypsin | ||||||||
MM | 215 (71.4) | 222 (64.5) | 1 (-) | 1 (-) | 64 (79) | 115 (71.4) | 1 (-) | 1 (-) |
MS | 65 (21.6) | 98 (28.5) | 0.66 (0.46—0.93) | 0.66 (0.46—0.96) | 15 (18.5) | 39 (24.2) | 0.73 (0.38—1.36) | 0.67 (0.33—1.29) |
MZ | 9 (3) | 15 (4.4) | 0.78 (0.36—1.65) | 0.64 (0.26—1.49) | 1 (1.2) | 3 (1.9) | 0.85 (0.04—7.05) | 0.74 (0.04—6.21) |
SZ | 4 (1.3) | 2 (0.6) | 1.97 (0.38—14.38) | 1.70 (0.32—12.47) | 0 (0) | 2 (1.2) | - | - |
SS | 8 (2.7) | 7 (2) | 1.14 (0.41—3.17) | 1.19 (0.42—3.48) | 1 (1.2) | 2 (1.2) | 0.87 (0.04—9.37) | 0.7 (0.03—7.55) |
ETS exposure | ||||||||
No | 158 (52.5) | 176 (51.2) | - | 1 (-) | 68 (84) | 126 (78.3) | - | 1 (-) |
Yes | 143 (47.5) | 168 (48.8) | - | 0.94 (0.68—1.29) | 13 (16) | 35 (21.7) | - | 0.67 (0.32—1.36) |
Radon exposure | ||||||||
< 200 Bq/m3 | 171 (56.8) | 225 (65.4) | - | 1 (-) | 49 (60.5) | 90 (55.9) | - | 1 (-) |
> = 200 Bq/m3 | 130 (43.2) | 119 (34.6) | - | 1.43 (1.03—1.97) | 32 (39.5) | 71 (44.1) | - | 0.87 (0.5—1.53) |
AAT genotype and risk of LC in persons aged < 65 years | AAT genotype and risk of LC in persons aged over 65 years | |||||||
Variable | Cases, n (%) | Controls, n (%) | Adjusted ORa (95% CI) | Adjusted ORb (95% CI) | Cases, n (%) | Controls, n (%) | Adjusted ORa (95% CI) | Adjusted ORb (95% CI) |
Alpha-1 antitrypsin | ||||||||
MM | 99 (75.6) | 155 (69.2) | 1 (-) | 1 (-) | 180 (71.7) | 182 (64.8) | 1 (-) | 1 (-) |
MS | 22 (16.8) | 60 (26.8) | 0.61 (0.36—1.02) | 0.55 (0.31—0.95) | 58 (23.1) | 77 (27.4) | 0.72 (0.49—1.05) | 0.74 (0.49—1.1) |
MZ | 5 (3.8) | 7 (3.1) | 0.92 (0.27—2.74) | 1.15 (0.33—3.76) | 5 (2) | 11 (3.9) | 0.67 (0.26—1.66) | 0.41 (0.13—1.17) |
SZ | 1 (0.8) | 1 (0.4) | 1.50 (0.06—38.35) | 1.16 (0.04—30.11) | 3 (1.2) | 3 (1.1) | 1.17 (0.21—6.49) | 1 (0.18—5.53) |
SS | 4 (3.1) | 1 (0.4) | 3.26 (0.62—23.94) | 6.24 (0.88—124.59) | 5 (2) | 8 (2.8) | 0.66 (0.2—2.03) | 0.63 (0.19—1.93) |
ETM exposure | ||||||||
No | 76 (58) | 134 (59.8) | - | 1 (-) | 150 (59.8) | 168 (59.8) | - | 1 (-) |
Yes | 55 (42) | 90 (40.2) | - | 0.87 (0.54—1.39) | 101 (40.2) | 113 (40.2) | - | 0.88 (0.61—1.26) |
Radon exposure | ||||||||
< 200 Bq/m3 | 74 (56.5) | 140 (62.5) | - | 1 (-) | 146 (58.2) | 175 (62.3) | - | 1 (-) |
> = 200 Bq/m3 | 57 (43.5) | 84 (37.5) | - | 1.38 (0.88—2.17) | 105 (41.8) | 106 (37.7) | - | 1.19 (0.84—1.7) |