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Table 4 Relationship between AAT genotype and risk of lung cancer, by sex and age

From: Alpha-1 antitrypsin deficiency and risk of lung cancer in never-smokers: a multicentre case–control study

 

AAT genotype and risk of LC among women never-smokers

AAT genotype and risk of LC among men never-smokers

Variable

Cases,

n (%)

Controls,

n(%)

Adjusted ORa (95% CI)

Adjusted ORb

(95% CI)

Cases,

n (%)

Controls, n(%)

Adjusted ORa

(95% CI)

Adjusted ORb

(95% CI)

Alpha-1 antitrypsin

        

MM

215 (71.4)

222 (64.5)

1 (-)

1 (-)

64 (79)

115 (71.4)

1 (-)

1 (-)

MS

65 (21.6)

98 (28.5)

0.66 (0.46—0.93)

0.66 (0.46—0.96)

15 (18.5)

39 (24.2)

0.73 (0.38—1.36)

0.67 (0.33—1.29)

MZ

9 (3)

15 (4.4)

0.78 (0.36—1.65)

0.64 (0.26—1.49)

1 (1.2)

3 (1.9)

0.85 (0.04—7.05)

0.74 (0.04—6.21)

SZ

4 (1.3)

2 (0.6)

1.97 (0.38—14.38)

1.70 (0.32—12.47)

0 (0)

2 (1.2)

-

-

SS

8 (2.7)

7 (2)

1.14 (0.41—3.17)

1.19 (0.42—3.48)

1 (1.2)

2 (1.2)

0.87 (0.04—9.37)

0.7 (0.03—7.55)

ETS exposure

        

No

158 (52.5)

176 (51.2)

-

1 (-)

68 (84)

126 (78.3)

-

1 (-)

Yes

143 (47.5)

168 (48.8)

-

0.94 (0.68—1.29)

13 (16)

35 (21.7)

-

0.67 (0.32—1.36)

Radon exposure

        

 < 200 Bq/m3

171 (56.8)

225 (65.4)

-

1 (-)

49 (60.5)

90 (55.9)

-

1 (-)

 >  = 200 Bq/m3

130 (43.2)

119 (34.6)

-

1.43 (1.03—1.97)

32 (39.5)

71 (44.1)

-

0.87 (0.5—1.53)

 

AAT genotype and risk of LC in persons aged < 65 years

 

AAT genotype and risk of LC in persons aged over 65 years

Variable

Cases,

n (%)

Controls,

n (%)

Adjusted ORa

(95% CI)

Adjusted ORb

(95% CI)

Cases,

n (%)

Controls,

n (%)

Adjusted ORa

(95% CI)

Adjusted ORb

(95% CI)

Alpha-1 antitrypsin

        

MM

99 (75.6)

155 (69.2)

1 (-)

1 (-)

180 (71.7)

182 (64.8)

1 (-)

1 (-)

MS

22 (16.8)

60 (26.8)

0.61 (0.36—1.02)

0.55 (0.31—0.95)

58 (23.1)

77 (27.4)

0.72 (0.49—1.05)

0.74 (0.49—1.1)

MZ

5 (3.8)

7 (3.1)

0.92 (0.27—2.74)

1.15 (0.33—3.76)

5 (2)

11 (3.9)

0.67 (0.26—1.66)

0.41 (0.13—1.17)

SZ

1 (0.8)

1 (0.4)

1.50 (0.06—38.35)

1.16 (0.04—30.11)

3 (1.2)

3 (1.1)

1.17 (0.21—6.49)

1 (0.18—5.53)

SS

4 (3.1)

1 (0.4)

3.26 (0.62—23.94)

6.24 (0.88—124.59)

5 (2)

8 (2.8)

0.66 (0.2—2.03)

0.63 (0.19—1.93)

ETM exposure

        

No

76 (58)

134 (59.8)

-

1 (-)

150 (59.8)

168 (59.8)

-

1 (-)

Yes

55 (42)

90 (40.2)

-

0.87 (0.54—1.39)

101 (40.2)

113 (40.2)

-

0.88 (0.61—1.26)

Radon exposure

        

 < 200 Bq/m3

74 (56.5)

140 (62.5)

-

1 (-)

146 (58.2)

175 (62.3)

-

1 (-)

 >  = 200 Bq/m3

57 (43.5)

84 (37.5)

-

1.38 (0.88—2.17)

105 (41.8)

106 (37.7)

-

1.19 (0.84—1.7)

  1. aAdjusted for age
  2. bAdjusted for age, exposure to ETS, and residential radon
  3. AAT alpha-1 antitrypsin, ETS environmental tobacco smoke