Table 1 Characteristics of individuals included in the study
Variable | Cases, n (%) | Controls, n (%) |
|---|---|---|
N | 457 (42) | 631 (58) |
Median age (P25—P75) | 70 (61–78) | 66 (58–75) |
Gender | ||
Female | 364 (79.6) | 429 (68.0) |
Male | 93 (20.4) | 202 (32.0) |
Educational level | ||
No formal education | 156 (34.1) | 177 (28.1) |
Primary education | 210 (46.0) | 293 (46.4) |
Secondary education | 44 (9.6) | 86 (13.6) |
University education | 47 (10.3) | 75 (11.9) |
Exposure to residential radon (Bq/m3) | ||
< 200 | 276 (60.4) | 431 (68.3) |
≥ 200 | 181 (39.6) | 200 (31.7) |
Exposure to environmental tobacco smoke | ||
Yes | 193 (42.2) | 259 (41.0) |
No | 264 (57.8) | 372 (59.0) |
Histological type | ||
Adenocarcinoma | 356 (77.9) | |
Squamous cell carcinoma | 35 (7.7) | |
Small-cell carcinoma | 28 (6.1) | |
Large-cell carcinoma | 11 (2.4) | |
Other histological types | 27 (5.9) | |
AAT mutations | ||
PI*S | ||
Not present | 357 (78.1) | 453 (71.8) |
Heterozygous | 91 (19.9) | 168 (26.6) |
Homozygous | 9 (2.0) | 10 (1.6) |
PI*Z | ||
Not present | 440 (96.3) | 606 (96.0) |
Heterozygous | 17 (3.7) | 25 (4.0) |
Homozygous | 0 | 0 |