Fig. 1
From: Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma
PFKFB3 protein is overexpressed in human ccRCC specimens and positively correlates with late TNM stage and low prognostic odds in ccRCC cases. (a) Representative images of juxta-tumoral healthy biopsies with down-regulated PFKFB3 expression. (b) ccRCC biopsy imaging, with high expression of PFKFB3. (c) H-score plot for PFKFB3 in ccRCC tissues (n = 90) and adjacent normal tissues (n = 90). (ccRCC = 131.52 ± 5.61 vs. Normal = 72.36 ± 4.55, P < 0.01). (d-e) H-score of PFKFB3 at multiple stages (TMN) and grades (Fuhrman) in ccRCC cases. (f) Kaplan-Meier overall survival times in ccRCC cases based on PFKFB3 expression (mean ± SD. *, P < 0.05; **, P < 0.01)