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Table 1 Details of studies examining BRCA1 and BRCA2 genes in North Africa

From: Prevalence of specific and recurrent/founder pathogenic variants in BRCA genes in breast and ovarian cancer in North Africa

 

Number of patients

BRCA

carriers

Mean age

Methods

Covered gene region

Morocco

Laarabi et al. (2011) [8]

8

6

NA

Direct sequencing

All

Tazzite et al. (2012) [9]

40

10

38

Direct sequencing

All

Laraqui et al. (2013) [10]

121

7

44

Direct sequencing

BRCA1

Elkhachibi et al. (2015) [11]

71

2

41

HRM, Direct sequencing

Exon11(BRCA1)

Jouali et al. (2016) [12]

15

6

47

NGS

All

Quiles et al. (2016) [13]

11

8

36.5

Direct sequencing

Exon20 (BRCA1)

Laarabi et al. (2017) [14]

122

14

 

Direct sequencing (51 patients), NGS (23 patients), Target screening (BRCA2 exon 10,48 patients)

All, Exon10 (BRCA2)

El Ansari et al. (2020) [15]

64

18

42

NGS

All

Bakkach et al. (2020) [16]

33

4

35

NGS

All

Mansouri et al (2020) [17]

32

7

45

NGS

All

Jouali et al. (2020) [18]

39

1

46

NGS

All

Algeria

Uhrhammeret al. (2008) [19]

51

5

31.5

Direct sequencing, MLPA

BRCA1

Cherbal et al. (2010) [20]

86

10

NA

Direct sequencing, MLPA

All

Henouda et al. (2016) [21]

40

8

36.6

Direct sequencing, MLPA

All

Boulenouar et al. (2018) [22]

50

4

NA

Direct sequencing, MLPA

All

Mehemmai et al. (2019) [23]

113

7

44

Direct sequencing, NGS

Exon3, 4,and 10 (BRCA1), Exon10 (BRCA2)

Tunisia

Troudi et al. (2007) [24]

36

7

56.8

Direct sequencing

All

Troudi et al. (2008) [25]

32

5

46.5

Direct sequencing

BRCA1

Mahfoudh et al. (2011) [26]

24

6

41

Direct sequencing

BRCA1

Riahi et al. (2013) [27]

48

12

NA

Direct sequencing

All

Fourati et al. (2014) [28]

66

12

45

Direct sequencing

BRCA1 (5,20, and

part of 11),

BRCA2 (10,11)

Msolly et al. (2015) [29]

17

1

45.8

Direct sequencing

All

Mahfoudh et al. (2019) [30]

33

2

53.8

Direct sequencing

All

Mighri et al. (2020) [31]

112

9

NA

Direct sequencing, NGS

All

Guerfali et al. (2021) [32]

134

19

NA

NGS

All

  1. HRM: High Resolution Melt, MLPA: Multiplex Ligation-dependent Probe Amplification, NGS: Next generation sequencing, NA: not available