Table 2 Examples of functional important genes with core promoter mutation
From: Core promoter mutation contributes to abnormal gene expression in bladder cancer
Items | Mutation | Co-promoter position | #Carrier | Expression |
|---|---|---|---|---|
A. Pathways with core promoter mutated genes | ||||
 Deregulated metabolism | Somatic Germline |  |  | |
 Differentiation | Somatic Germline |  |  | |
 Sustained angiogenesis | Somatic Germline |  |  | |
 Regulation of mitotic cell cycle phase transition | Somatic |  |  |  |
 Cellular response to peptide hormone stimulus | Somatic |  |  |  |
 Selective advantage | Somatic |  |  |  |
 Evading apoptosis | Germline |  |  |  |
 Evading the immune system | Germline |  |  |  |
 Tissue invasion and metastasis | Germline |  |  |  |
 DNA repair | Germline |  |  |  |
B. Examples of cancer related genes | ||||
 TERT | Somatic | −66 | 3 | + 7.5 |
 PRKAR2B | Somatic | 93 | 2 | −6.2 |
 SMUG1 | Germline | 90 | 2 | + 2.1 |
 GAB2 | Germline | −60 | 3 | −2.3 |