Fig. 3
From: Core promoter mutation contributes to abnormal gene expression in bladder cancer
GO classification and KEGG pathways of core promoter-mutated genes. A. GO classification of somatic core promoter-mutated genes; B. GO classification of germline core promoter-mutated genes; C. KEGG pathway of TERT involved in cancer (https://www.kegg.jp/pathway/map05200). The C228T in the core promoter of TERT generated a new Ets binding motif, altered TERT expression, and promoted cellular immortality. D. KEGG pathway of GAB2 involved in cancer (https://www.kegg.jp/pathway/ko05220). GAB2 involves in MAPK and PI3K-Akt signal pathways in immune-response and apoptosis. A germline A > C mutation at − 60 altered the sequence from “CCCACC” to “CCCCCC”, caused decreased GAB2 expression in bladder cancer (Table S7). Black bar: statistical significance of gene group; white bar: number of genes enriched in the group; full arrow: direct effects; dotted line arrow: indirect effects