Fig. 2

Core promoter mutated genes with altered gene expression in bladder cancer. The volcano plots showed the altered expression of core promoter mutated genes between cancer and adjacent normal samples based on RNA-seq data. X-axis represented fold changes of increased or decreased expression, and Y-axis represented distribution of the genes with altered expression at -log10 scale. The pie charts displayed the number of gene with altered expression. A. altered expression of somatic core promoter mutated genes; B. somatic core promoter mutated genes with altered expression; C. altered expression of germline core promoter mutated genes; D. germline core promoter mutated genes with altered expression. E. luciferase activities with mutated core promoters. Luciferase activities in 10 mutated core promoters were compared with the corresponding wild-type core promoters. Three independent tests were performed for each core promoter. *refers to these with significant differences