Table 4 Univariate (a) and multivariate (b) Cox regression model of prognosis in patients with lung adenocarcinoma
Clinicopathologic variable | Total (N) | HR (95% CI) | P-value |
|---|---|---|---|
a. | |||
 Gender (Male vs. Female) | 502 | 0.970(0.724-1.298) | 0.837 |
 Age (> 70 vs. <=70) | 502 | 1.464(1.083-1.979) | 0.013 |
 Number pack years smoked (> 40 vs. <=40) | 502 | 0.870(0.627-1.207) | 0.405 |
 EGFR mutation status (Yes vs. No) | 272 | 1.261(0.800-1.987) | 0.319 |
 KRAS mutation status (Yes vs. No) | 308 | 1.253(0.782-2.007) | 0.348 |
 ALK mutation status (Yes vs. No) | 242 | 1.655(0.925-2.961) | 0.090 |
 T stage (T2&T3&T4 vs. T1) | 502 | 1.666(1.182-2.347) | 0.004 |
 N stage (N2&N3 vs. N0&N1) | 502 | 2.265(1.584-3.239) | < 0.001 |
 M stage (M1 vs. M0) | 502 | 2.143(1.251-3.672) | 0.006 |
 Pathologic stage (Stage III/IV vs. Stage I/II) | 502 | 2.609(1.911-3.561) | < 0.001 |
 CANT1 (High vs. Low) | 502 | 1.547(1.143-2.094) | 0.005 |
b. | |||
 Age (> 70 vs. <=70) |  | 1.341(0.984-1.827) | 0.063 |
 T stage (T2&T3&T4 vs. T1) |  | 1.467(1.034-2.081) | 0.032 |
 N stage (N2&N3 vs. N0&N1) |  | 0.881(0.500-1.550) | 0.660 |
 Pathologic stage (Stage III/ IV vs. Stage I/II) |  | 2.290(1.395-3.758) | 0.001 |
 CANT1 (High vs. Low) |  | 1.490(1.081-2.055) | 0.015 |