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Table 1 Biodistribution (%ID/g) of Lip-99mTc-HYNIC-ASON in Tumor-Bearing Mice

From: Radiosynthesis of a novel antisense imaging probe targeting LncRNA HOTAIR in malignant glioma

Tissue

1 h

2 h

3 h

4 h

6 h

Heart

1.68 ± 0.38

1.73 ± 0.33

1.32 ± 0.1

0.82 ± 0.15

0.59 ± 0.21

Blood

1.37 ± 0.5

0.81 ± 0.58

0.56 ± 0.4

0.66 ± 0.17

0.18 ± 0.27

Liver

1.22 ± 0.42

1.28 ± 0.52

0.83 ± 0.32

0.88 ± 0.08

0.61 ± 0.29

Spleen

0.61 ± 0.05

0.45 ± 0.05

0.38 ± 0.14

0.29 ± 0.04

0.21 ± 0.04

Lung

1.5 ± 0.24

1.37 ± 0.35

1.01 ± 0.37

0.58 ± 0.08

0.37 ± 0.22

Kidney

6.25 ± 1.31

5.36 ± 1

5.38 ± 1.52

3.95 ± 0.67

2.63 ± 0.55

Stomach

2.3 ± 1.29

2.86 ± 0.46

2.7 ± 0.57

1.46 ± 0.14

1.31 ± 0.43

Small intestine

3.43 ± 0.82

3.17 ± 0.35

3.06 ± 0.82

2.21 ± 0.66

2.14 ± 0.67

bladder

11.89 ± 0.9

11.7 ± 0.75

9.81 ± 1.62

9.12 ± 1.66

8.75 ± 0.95

Skeletal muscle

0.81 ± 0.06

1.73 ± 0.23

2.68 ± 2.35

1.01 ± 0.48

1.76 ± 2.37

Bone

0.63 ± 0.32

1.96 ± 1.53

0.46 ± 0.32

0.87 ± 0.6

0.66 ± 0.6

Tumor

1.73 ± 0.13

1.22 ± 0.1

1.06 ± 0.22

0.82 ± 0.22

0.58 ± 0.1

  1. Each value represents average of 4 mice ± SD