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Table 2 Adverse events

From: Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study

  Grade 1 Grade 2 Grade 3 Grade 4
Adverse Reactions at least possibly related to glucarpidase (All)
Abdominal pain 1 (2)
Dyspnea 1 (2)
Fecal incontinence 1 (2)
Flushed face 1 (2)
Headache 1 (2)
Nausea 3 (5)
Adverse Reactions at least possibly related to methotrexate (All grade 3 and higher, most common > 10% grade 1–2)
Alanine aminotransferase increased 12 (22) 2 (4) 1 (2)
Anemia 10 (18) 12 (22) 5 (9)
Aspartate aminotransferase increased 17 (31) 2 (4) 1 (2)
Blood billirubin increased 11 (20) 3 (5)
Creatinine increased 2 (4) 3 (5)
Hypoalbuminemia 10 (18) 2 (4)
Hypokalemia 7 (13) 1 (2) 2 (4)
Lung infection 1 (2)
Lymphocyte count decreased 7 (13) 15 (27) 10 (18)
Nausea 8 (15) 4 (7)
White blood cell count decreased 8 (15) 3 (5) 1 (2)
  1. -, not observed