|
Adverse Reactions at least possibly related to glucarpidase (All)
|
|
Abdominal pain
|
–
|
1 (2)
|
–
|
–
|
|
Dyspnea
|
–
|
1 (2)
|
–
|
–
|
|
Fecal incontinence
|
1 (2)
|
–
|
–
|
–
|
|
Flushed face
|
1 (2)
|
–
|
–
|
–
|
|
Headache
|
–
|
1 (2)
|
–
|
–
|
|
Nausea
|
3 (5)
|
–
|
–
|
–
|
|
Adverse Reactions at least possibly related to methotrexate (All grade 3 and higher, most common > 10% grade 1–2)
|
|
Alanine aminotransferase increased
|
12 (22)
|
2 (4)
|
1 (2)
|
–
|
|
Anemia
|
10 (18)
|
12 (22)
|
5 (9)
|
–
|
|
Aspartate aminotransferase increased
|
17 (31)
|
2 (4)
|
1 (2)
|
–
|
|
Blood billirubin increased
|
11 (20)
|
3 (5)
|
–
|
–
|
|
Creatinine increased
|
2 (4)
|
3 (5)
|
–
|
–
|
|
Hypoalbuminemia
|
10 (18)
|
2 (4)
|
–
|
–
|
|
Hypokalemia
|
7 (13)
|
1 (2)
|
2 (4)
|
–
|
|
Lung infection
|
–
|
–
|
1 (2)
|
–
|
|
Lymphocyte count decreased
|
7 (13)
|
15 (27)
|
10 (18)
|
–
|
|
Nausea
|
8 (15)
|
4 (7)
|
–
|
–
|
|
White blood cell count decreased
|
8 (15)
|
3 (5)
|
1 (2)
|
–
|
