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Table 1 Patient Characteristics

From: Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study

Sex, No. (%)

Men

6 (75%)

Women

2 (25%)

Median age, years (range)

70 (57–78)

KPS, (range)

70 (50–100)

Location, No. (%)

 

Primary

7 (87.5%)

Secondary

1 (12.5%)

Disease Status

Newly diagnosed

7 (87.5%)

Recurrent

1 (12.5%)

Leptomeningeal disease

3 (37.5%)

Ocular disease

0 (0%)

Median Prior Regimens, No. (range)

0 (0–3)

MTX 3 g/m2(patients)

4

Glucarpidase 2000u

17 doses

Glucarpidase 1000u

11 doses

MTX 6 g/m2(patients)

4

Glucarpidase 2000u

18 doses

Glucarpidase 1000u

9 doses