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Fig. 2 | BMC Cancer

Fig. 2

From: Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study

Fig. 2

Effect of anti-glucarpidase antibodies on serum methotrexate (MTX concentrations after glucarpidase. (A) MTX concentrations pre- and post-glucarpidase in patients with and without anti-glucarpidase antibody formation. Blue line reflects MTX concentrations in patient with anti-glucarpidase antibodies and red, without. (B) Heat map of MTX rebound data as % of pre-glucarpidase MTX concentration. Cell label represents dose of glucarpidase, either 2000 or 1000 units. Thickened border indicates presence of neutralizing anti-glucarpidase antibody. Patient 6 cycle 1 results not available due to sample loss

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BMC Cancer

ISSN: 1471-2407

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