Factors associated with response to compression-based physical therapy for secondary lower limb lymphedema after gynecologic cancer treatment: a multicenter retrospective study

Yoshihara, Masato; Kitamura, Kaoru; Tsuru, Satoko; Shimono, Ryoko; Sakuda, Hiromi; Mayama, Michinori; Tano, Sho; Uno, Kaname; Ukai, Mayu Ohno; Kishigami, Yasuyuki; Oguchi, Hidenori; Hirota, Akio

doi:10.1186/s12885-021-09163-y

Table 2 Univariate and multiple regression analysis for changes of lower limb circumference

From: Factors associated with response to compression-based physical therapy for secondary lower limb lymphedema after gynecologic cancer treatment: a multicenter retrospective study

		Early phase				Maintenance phase
		Univariate analysis		Multivariate regression analysis		Univariate analysis		Multivariate regression analysis
Characteristics	Categories		P value	Standardized Coefficient	P value		P value	Standardized Coefficient	P value
Age, CC^a		− 0.073	0.061	− 0.111	0.007	− 0.098	0.010	− 0.134	< 0.001
BMI, CC^a		− 0.299	< 0.001	0.447	< 0.001	− 0.348	< 0.001	0.456	< 0.001
Type of cancer, cm (SD)^b	Cervical cancer	− 7.20 (7.53)	0.268	referent		− 9.65 (9.64)	0.008	referent
	Endometrial cancer	− 6.26 (7.01)		0.034	0.444	− 7.40 (9.64)		0.087	0.037
	Ovarian cancer	− 6.27 (7.37)		0.014	0.755	− 7.28 (8.81)		0.029	0.484
Lymphadenectomy, cm (SD)^b	Pelvic	− 4.45 (9.90)	0.014	referent		− 8.46 (12.05)	< 0.001	referent
Lymphadenectomy, cm (SD)^b	Pelvic + paraaorta	− 6.57 (8.17)		− 0.022	0.596	− 4.78 (9.29)		− 0.055	0.132
Chemotherapy, cm (SD)^b	Yes	− 2.88 (10.66)	0.002	0.011	0.825	− 1.75 (11.24)	< 0.001	− 0.010	0.140
Chemotherapy, cm (SD)^b	No	− 6.88 (9.24)				− 8.29 (8.28)
Radiotherapy, cm (SD)^b	Yes	− 7.28 (12.29)	0.242	0.108	0.012	− 9.11 (14.53)	0.074	0.082	0.040
Radiotherapy, cm (SD)^b	No	− 6.35 (8.22)				− 7.16 (9.65)
Stage, cm (SD)^b	I	− 1.53 (5.32)	< 0.001	referent		− 0.13 (4.66)	< 0.001	referent
	II	− 5.81 (7.61)		0.044	0.704	− 6.97 (9.32)		− 0.168	0.141
	Late in II	− 9.61 (10.57)		0.053	0.640	− 11.96 (12.65)		− 0.093	0.407
	III	− 27.32 (31.34)		0.01	0.849	− 31.76 (38.43)		− 0.056	0.260
Circumference, CC^a		− 0.608	< 0.001	− 0.828	< 0.001	− 0.671	< 0.001	− 0.920	< 0.001
MLD, cm (SD)^b	Yes	− 6.54 (9.35)	0.768	0.013	0.794	− 8.17 (11.52)	0.012	0.011	0.796
MLD, cm (SD)^b	No	− 6.87 (9.40)				− 5.40 (8.60)

Statistically significant results are marked in bold
BMI Body mass index, MLD Manual lymphatic drainage
^aData are expressed as a correlation coefficient (CC)
^bData are expressed as the group mean (standard deviation [SD])

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