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Table 3 Follow-up after neoadjuvant treatment in case of total mesorectal excision (TME)

From: THUNDER 2: THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI guided radiotherapy

  Follow up time (months)
  1.5 3 6 9 12 18 24 30 36
Medical history, blood sample and DRE x x x x x x x x x
Surgical histology x         
Total body CT   x   x   x   x  
Abdomen US    x   x   x   x
Colonoscopy     x      x
QoL questionnaries   x    x   x   
Acute toxicity
Grading (CTCAE v. 4.0)
  x        
Late toxicity
Grading (CTCAE v. 4.0)
   x x x x x x x
  1. Blood sample includes blood count with differential leukocyte count and CEA. The quality of life (QoL) questionnaires assess sexual (FSFI—Female sexual function index—and IIEF—International Index of Erectile Function—questionnaires) and bowel function (MSKCC BFI-Memorial Sloan-Kettering Cancer Center Bowel Function Instrument). DRE Digital rectal examination; CT Computed tomography; US Ultrasound; CTCAE Common terminology criteria for adverse events