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Table 2 Follow-up after neoadjuvant treatment in case of watch and wait (W&W) or local excision (LE)

From: THUNDER 2: THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI guided radiotherapy

  Follow up time (months)
  3 6 9 12 15 18 21 24 30 36
Medical history, blood sample and DRE x x x x x x x x x x
Rectoscopy x x x x x x x x x x
MRI   x   x   x   x   x
Total body CT     x     x   x
Colonoscopy     x       x
Abdomen US x   x   x   x   x  
QoL questionnaries x    x     x   
Acute toxicity
Grading (CTCAE v. 4.0)
x          
Late toxicity
Grading (CTCAE v. 4.0)
  x x x x x x x x x
  1. Blood sample includes blood count with differential leukocyte count and CEA. The quality of life (QoL) questionnaires assess sexual (FSFI—Female sexual function index—and IIEF—International Index of Erectile Function—questionnaires) and bowel function (MSKCC BFI-Memorial Sloan-Kettering Cancer Center Bowel Function Instrument). DRE Digital rectal examination; MRI Magnetic resonance imaging; CT Computed tomography; US Ultrasound; CTCAE Common terminology criteria for adverse events