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Table 2 Multivariate analysis of Cox regression for 5-year RFS and OS in right-side colon cancer

From: Number of negative lymph nodes with a positive impact on survival of stage III colon cancer; a retrospective observation study for right side and left side colon

Variables

RFS

 

OS

 
 

HR (95% CI)

P-value

HR (95% CI)

P-value

Sex

 Female

1

 

1

 

 Male

1.181 (0.898–1.554)

0.233

0.963 (0.753–1.231)

0.763

Age

 < 50 year-old

1

 

1

 

 50–65 year-old

1.434 (0.925–2.223)

0.107

1.144 (0.749–1.745)

0.534

 65–80 year-old

1.114 (0.718–1.729)

0.630

1.361 (0.910–2.034)

0.134

 ≥80 year-old

1.249 (0.704–2.216)

0.446

2.951 (1.856–4.692)

< 0.001

CEA, pre-operation

 ≥5 ng/mL

1

 

1

 

 < 5 ng/mL

0.611 (0.463–0.806)

< 0.001

0.717 (0.560–0.918)

0.008

NLR, pre-operation

 ≥ 2.87

1

 

1

 

 <  2.87

1.054 (0.796–1.397)

0.713

0.864 (0.664–1.124)

0.277

Histology type

 Adenocarcinoma

1

 

1

 

 Signet ring cell

1.509 (0.528–4.313)

0.443

2.691 (1.128–6.418)

0.026

 Mucinous

0.927 (0.582–1.477)

0.751

1.038(0.693–1.554)

0.856

Histology grade

 Poorly

1

 

1

 

 Moderate

1.231 (0.823–1.842)

0.311

1.262 (0.884–1.802)

0.200

 Well

0.792 (0.396–1.583)

0.509

0.719 (0.381–1.356)

0.308

NLN

 <  27

1

 

1

 

 ≥ 27

0.613 (0.463–0.812)

0.001

0.626 (0.487–0.804)

< 0.001

Stage III

 IIIA

1

 

1

 

 IIIB

8.661 (1.207–62.167)

0.032

1.990 (0.809–4.894)

0.134

 IIIC

19.874 (2.746–143.811)

0.003

4.030 (1.612–10.076)

0.003

Adjuvant C/T

 No

1

 

1

 

 Yes

0.702 (0.484–1.018)

0.062

0.517 (0.387–0.690)

<  0.001

  1. RFS relapse –free survival, OS overall survival, CEA carcinoembryonic antigen, NLR neutrophil to lymphocyte ratio, NLN negative lymph node number, Adjuvant C/T adjuvant chemotherapy