Table 2 Results of the meta-regression assessing which factors are associated with AUC improvement of SNP-enhanced models compared with non-SNP enhanced models

Number of cases

−0.000016

−0.0000243, − 7.63*10^− 6

0.002

0.027

Number of SNPs

0.0004986

0.0000216, 0.0009757

0.042

0.170

Year of publication

0.0021238

−0.0012521, 0.0054998

0.191

0.468

AUC of non-SNP enhanced model

−0.3485498

−0.4171094, − 0.2799903

< 0.001

< 0.001

Ethnicity (Asian vs European)

0.0313164

0.0151622, 0.0474705

0.002

0.023

Number of traditional risk factors in the model

−0.0000322

−0.0010623, 0.0009979

0.946

1.000

Gender considered in the construction of the model

−0.0086505

−0.0191019, 0.001801

0.095

0.316