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Table 2 Results of the meta-regression assessing which factors are associated with AUC improvement of SNP-enhanced models compared with non-SNP enhanced models

From: Polygenic risk prediction models for colorectal cancer: a systematic review

  Coefficient 95% Confidence Interval p-value Adjusted p-value
Number of cases −0.000016 −0.0000243, − 7.63*10− 6 0.002 0.027
Number of SNPs 0.0004986 0.0000216, 0.0009757 0.042 0.170
Year of publication 0.0021238 −0.0012521, 0.0054998 0.191 0.468
AUC of non-SNP enhanced model −0.3485498 −0.4171094, − 0.2799903 < 0.001 < 0.001
Ethnicity (Asian vs European) 0.0313164 0.0151622, 0.0474705 0.002 0.023
Number of traditional risk factors in the model −0.0000322 −0.0010623, 0.0009979 0.946 1.000
Gender considered in the construction of the model −0.0086505 −0.0191019, 0.001801 0.095 0.316
  1. SNP single nucleotide polymorphism