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Fig. 6 | BMC Cancer

Fig. 6

From: Somatic mutations in collagens are associated with a distinct tumor environment and overall survival in gastric cancer

Fig. 6

Model of impact of cancer cell secreted collagens on tumors. Collagens originate from either the cancer or stroma cells. Truncation and missense collagen mutants reorganize the tumor microenvironment decreasing multiple processes that increase drug sensitivity and reduce metastasis risk including reduced EMT, less local collagen around the cancer cells, a more disorganized collagen structure, and increased infiltration of cytotoxic immune cells and drugs

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BMC Cancer

ISSN: 1471-2407

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