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Fig. 4 | BMC Cancer

Fig. 4

From: Somatic mutations in collagens are associated with a distinct tumor environment and overall survival in gastric cancer

Fig. 4

Tumors with collagen mutations have distinct expression of cancer hallmarks and tumor environments. A. Representative enrichment plots from pre-rank GSEA suggest upregulation of E2F regulated transcripts and down-regulation of the expression of the matrisome in tumors with collagen mutations. TCGA stomach tumors were classified by collagen mutation status and pre-ranked GSEA revealed associations with the indicated gene set. B. Heat map of normalized enrichment scores of the cancer hallmark, immune cell, and NABA ECM gene sets. Red indicates higher expression in mutant tumors and blue indicates higher expression in wild-type tumors. Nonsignificant and modest enrichment scores between − 1.5 and 1.5 are in white. In the full STAD TCGA cohort, tumors with any collagen mutation or with only mutations in COL7A1 or COL11A1 showed similar patterns. C. Heatmap of gene sets in MSS only tumors. D. Heatmaps of gene sets in MSIH only tumors reveal a more diverse pattern of enrichment. All heatmaps generated in Morpheus [38]

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