Fig. 2

Identification of collagen genes mutations associated with overall survival. A. Patients with tumors that harbor at least one mutation in a collagen gene, have significantly better outcomes in the STAD TCGA cohort. Patients with tumors with at least one collagen mutation of the type indicated in red. Wild-type tumors in blue. Log-rank test p-values shown. Truncation mutations in any collagen gene were associated with better outcomes while nonsynonymous missense mutations were not associated with overall survival. Both missense and truncation mutations in COL5A2 were associated with longer overall survival. B. Schematic of approach to identify tumors with combinations of mutated collagens associated survival more significantly relative to background accounting for mutation rate, gene size and number of patients. C. Frequency of the inclusion of each collagen gene with a truncation mutation in a combination significantly associated with overall survival. A representative combination of collagen genes strongly associated with overall survival curve and the oncoprint. D. Identification of collagen genes with truncation mutations in MSIH tumors most strongly associated with overall survival. Frequency of the inclusion of each collagen in subsets consisting of 2 and 3 collagen genes with truncation only mutations in MSIH tumors