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Table 1 Baseline characteristics of the study participants

From: Colorectal Cancer in North-Eastern Iran: a retrospective, comparative study of early-onset and late-onset cases based on data from the Iranian hereditary colorectal cancer registry

Characteristic Early-onset CRC (%) Late-onset CRC (%) P-value
Gender (n = 562)
 Female (n = 288) 124 (55.9) 164 (48.2) 0.046c
 Male (n = 274) 98 (44.1) 176 (51.8)  
Tumour location (n = 473)
 Proximal (n = 53) 16 (8.9) 37 (12.6)  
 Distal (n = 287) 111 (62.0) 176 (59.9) 0.47c
 Rectum (n = 133) 52 (29.1) 81 (27.6)  
Amsterdam II (n = 410)
 Criteria absent (n = 395) 151 (93.8) 244 (98.0) 0.03c
 Criteria present (n = 15) 10 (6.2) 5 (2.0)  
Revised Bethesda (n = 408)
 Criteria absent (n = 212) 14 (8.0) 198 (84.6) 0.001c
 Criteria present (n = 196) 160 (92.0) 36 (15.4)  
History of CRC in FDR (n = 437)
 No (n = 395) 162 (90.5) 235 (90.3) 0.9c
 Yes (n = 42) 17 (9.5) 25 (9.7)  
History of CRC in SDR (n = 437)
 No (n = 399) 154 (86.0) 245 (95.0) 0.001c
 Yes (n = 38) 25 (14.0) 13 (5.0)  
History of CRC in FDR or SDR (n = 437)
 No (n = 362) 141 (78.8) 221 (85.7) 0.06c
 Yes (n = 75) 38 (21.2) 37 (14.3)  
History of CRC in FDR and SDR (n = 437)
 No (n = 432) 175 (97.8) 257 (99.6) 0.16d
 Yes (n = 5) 4 (2.2) 1 (0.4)  
non-CRC history of cancer in FDR (n = 437)
 No (n = 374) 155 (86.6) 219 (84.9) 0.6c
 Yes (n = 63) 24 (13.4) 39 (15.1)  
Family history of cancer (n = 437)
 Absent (n = 291) 114 (63.7) 177 (68.6) 0.3c
 Present (n = 146) 65 (36.3) 81 (31.4)  
CRC outcome group (n = 293)
 Recovered and discharged (n = 234) 103 (85.8) 131 (75.7) 0.03c
 Deceased at the hospital (n = 59) 17 (14.2) 42 (24.3)  
Mismatch repair status (n = 421)
 Proficient (n = 380) 143 (88.8) 237 (91.1) 0.39d
 Deficient (n = 41) 18 (11.2) 23 (8.9)  
At high risk for LSa (n = 421)
 No (n = 385) 143 (88.8) 242 (93.1)  
 Yes (n = 36) 18 (11.2) 18 (6.9) 0.14d
MMR-deficiencyb (n = 41 ( 18 (43.9) 23 (56.1)  
MLH1 (n = 27) 13 (48.1) 14 (51.9)  
PMS2 (n = 30) 13 (43.3) 17 (56.7) 0.3d
MSH2 (n = 9) 4 (44.4) 5 (55.6)  
MSH6 (n = 10) 5 (50.0) 5 (50.0)  
  1. CRC colorectal cancer, FDR first degree relative, SDR second degree relative, LS Lynch syndrome, MMR mismatch repair
  2. a CRCs with absent MMR proteins, and normal BRAF status (if MLH1 was absent)
  3. b Some MMR gene deficiencies included more than one protein, which explains why the sum exceeds 41
  4. c Analysis by Chi-square test
  5. d Analysis by Fisher’s exact test