Table 1 Baseline characteristics of the study participants
Characteristic | Early-onset CRC (%) | Late-onset CRC (%) | P-value |
|---|---|---|---|
Gender (n = 562) | |||
 Female (n = 288) | 124 (55.9) | 164 (48.2) | 0.046c |
 Male (n = 274) | 98 (44.1) | 176 (51.8) |  |
Tumour location (n = 473) | |||
 Proximal (n = 53) | 16 (8.9) | 37 (12.6) |  |
 Distal (n = 287) | 111 (62.0) | 176 (59.9) | 0.47c |
 Rectum (n = 133) | 52 (29.1) | 81 (27.6) |  |
Amsterdam II (n = 410) | |||
 Criteria absent (n = 395) | 151 (93.8) | 244 (98.0) | 0.03c |
 Criteria present (n = 15) | 10 (6.2) | 5 (2.0) |  |
Revised Bethesda (n = 408) | |||
 Criteria absent (n = 212) | 14 (8.0) | 198 (84.6) | 0.001c |
 Criteria present (n = 196) | 160 (92.0) | 36 (15.4) |  |
History of CRC in FDR (n = 437) | |||
 No (n = 395) | 162 (90.5) | 235 (90.3) | 0.9c |
 Yes (n = 42) | 17 (9.5) | 25 (9.7) |  |
History of CRC in SDR (n = 437) | |||
 No (n = 399) | 154 (86.0) | 245 (95.0) | 0.001c |
 Yes (n = 38) | 25 (14.0) | 13 (5.0) |  |
History of CRC in FDR or SDR (n = 437) | |||
 No (n = 362) | 141 (78.8) | 221 (85.7) | 0.06c |
 Yes (n = 75) | 38 (21.2) | 37 (14.3) |  |
History of CRC in FDR and SDR (n = 437) | |||
 No (n = 432) | 175 (97.8) | 257 (99.6) | 0.16d |
 Yes (n = 5) | 4 (2.2) | 1 (0.4) |  |
non-CRC history of cancer in FDR (n = 437) | |||
 No (n = 374) | 155 (86.6) | 219 (84.9) | 0.6c |
 Yes (n = 63) | 24 (13.4) | 39 (15.1) |  |
Family history of cancer (n = 437) | |||
 Absent (n = 291) | 114 (63.7) | 177 (68.6) | 0.3c |
 Present (n = 146) | 65 (36.3) | 81 (31.4) |  |
CRC outcome group (n = 293) | |||
 Recovered and discharged (n = 234) | 103 (85.8) | 131 (75.7) | 0.03c |
 Deceased at the hospital (n = 59) | 17 (14.2) | 42 (24.3) |  |
Mismatch repair status (n = 421) | |||
 Proficient (n = 380) | 143 (88.8) | 237 (91.1) | 0.39d |
 Deficient (n = 41) | 18 (11.2) | 23 (8.9) |  |
At high risk for LSa (n = 421) | |||
 No (n = 385) | 143 (88.8) | 242 (93.1) |  |
 Yes (n = 36) | 18 (11.2) | 18 (6.9) | 0.14d |
MMR-deficiencyb (n = 41 ( | 18 (43.9) | 23 (56.1) |  |
 MLH1 (n = 27) | 13 (48.1) | 14 (51.9) |  |
 PMS2 (n = 30) | 13 (43.3) | 17 (56.7) | 0.3d |
 MSH2 (n = 9) | 4 (44.4) | 5 (55.6) |  |
 MSH6 (n = 10) | 5 (50.0) | 5 (50.0) |  |