Roles of extended human papillomavirus genotyping and multiple infections in early detection of cervical precancer and cancer and HPV vaccination

Table 4 Logistic regression analyses of Odds ratio (OR) for CIN2+ vs ≤ CIN1 according to multiple vs. single HPV infection

hrHPV types	Single infection	Multiple infection	OR (95% CI)^†	P-value^††
hrHPV types	No. CIN2+/ total	No. CIN2+/ total	OR (95% CI)^†	P-value^††
16	194/667	85/353	0.8 (0.6-1.1)	0.144
18	16/230	0/35	NA	NA
31	15/88	3/39	0.4 (0.1-1.4)	0.132
33	23/71	5/48	0.2 (0.1-0.6)	0.004
35	8/38	2/21	0.5 (0.1-3.2)	0.462
39	0/85	0/0	NA	NA
45	1/23	0/9	NA	NA
51	3/121	2/10	11.0 (1.5-80.6)	0.018
52	13/199	2/71	0.4 (0.1-1.9)	0.248
56	1/58	4/26	6.5 (0.4-99.4)	0.180
58	26/193	20/99	1.6 (0.8-3.1)	0.178
59	2/43	0/13	NA	NA
66	3/67	1/7	4.9 (0.4-64.6)	0.224
68	3/97	5/24	8.8 (1.8-43.8)	0.008

^†The analysis was adjusted for age. ^††P-values from multiple comparisons were corrected at a Bonferroni threshold (P = 0.05/14 = 0.0036)
Abbreviations: CI confidence interval, CIN2+ cervical intraepithelial neoplasia 2 or worse, OR odds ratio, NA not available

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