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Table 4 Stability of CFT and CFP when alone or combined with 5-FU incubated up to 8 h in media as measured by LC-MS/MS [26]. A) CFP (50 μg/ml) ± 5-FU (8 μM and 16 μM). B) CFT (100 μg/ml) ± 5-FU (8 μM and 16 μM). P value (a) (between antibiotic alone and 5-FU (8 μM)); P value (b) (between antibiotic alone and 5-FU (16 μM)), n = 3

From: Ceftazidime and cefepime antagonize 5-fluorouracil’s effect in colon cancer cells

A) Stability test

CFP (50 μg/mL)

CFP (50 μg/mL) + 5-FU (8 μM)

CFP (50 μg/mL) + 5-FU (16 μM)

Pvalue (a)

Pvalue (b)

2 h

49.9 ± 9.5

45.3 ± 6.4

50.9 ± 0.6

0.3

0.5

8 h

48.8 ± 5.3

50.9 ± 7.0

47.2 ± 5.9

0.4

0.4

B) Stability test

CFT (100 μg/mL)

CFT (100 μg/mL) + 5-FU(8 μM)

CFT (100 μg/mL) + 5-FU(16 μM)

Pvalue (a)

Pvalue (b)

2 h

104.4 ± 2.5

112.1 ± 4.4

94.6 ± 7.5

0.1

0.1

8 h

103.4 ± 10.8

110.8 ± 11.3

103.4 ± 11.7

0.2

0.3