Table 1 Characteristics of study sites in Eastern Africa
Site | Tenwek Hospital | Ocean Road Cancer Institute (ORCI) | Muhimbili National Hospital (MNH) | Kamuzu Central Hospital (KCH) | Moi Teaching and Referral Hospital (MTRH) | Kilimanjaro Christian Medical Centre (KCMC) |
|---|---|---|---|---|---|---|
Location | Bomet, Kenya | Dar es Salaam, Tanzania | Dar es Salaam, Tanzania | Lilongwe, Malawi | Eldoret, Kenya | Moshi, Kilimanjaro |
Setting | Rural | Urban | Urban (two campuses, Upanga and Mloganzila) | Urban | Urban | Urban |
Type of Hospital | Faith-based hospital | National cancer (specialized) referral hospital | National referral hospital | National referral hospital | National referral hospital | Zonal referral hospital |
Recruitment start date | February 2019 | May 2019 | November 2019 | June 2021 | November 2021 | November 2021 |
Recruitment end datea | December 2022 | December 2022 | December 2022 | December 2022 | December 2022 | December 2022 |
Estimated annual new diagnoses of EC | 250 | 150 | 167 | 300 | 325 | 90 |
Forecasted annual recruitment | 220 | 130 | 150 | 160 | 275 | 80 |
Forecasted enrollment (total) | 862 | 476 | 472 | 253 | 320 | 93 |
Duration of enrollment | 47 months | 44 months | 38 months | 19 months | 14 months | 14 months |
Diagnostic modalities available | ||||||
 Endoscopy | Yes | No | Yes | Yes | Yes | Yes |
 Pathology | Referred to outside facility | Yes | Yes | Yes | Yes | Yes |
 X-ray / ultrasound | Yes | Yes | Yes | Yes | Yes | Yes |
 CT scan | Yes | Yes | Yes | Yes | Yes | Yes |
 PET scan | No | No | No | No | No | No |
 EUS | No | No | No | No | No | Mo |
Treatment modalities available | ||||||
 Chemotherapy | Yes | Yes | Yesa | Yes | Yes | Yes |
 Radiation | ||||||
  Brachytherapy (for EC) | No | No | No | No | No | No |
  EBRT | No | Yes | No | Planned 2022 | Yes | Referred to ORCI |
 Esophageal stents | Yes | No | Yes | Yes | Yes | Yes |
 Esophagectomy | Yes | No | Yes | No | Yes | No |
Supportive care | ||||||
 Availability of TPN | Yes | Yes | Yes | Yes | Yes | Yes |
 Capacity for gastrostomy tubes | Yes | No | Yes | Yes | Yes | Yes |
 Intensive care unit | Yes | No | Yes | Yes | Yes | Yes |
 Palliative care team | Yes | Yes | No | Yes | Yes | Yes |