Skip to main content

Table 3 Univariate and multivariate analyses of the factors determining disease free survival (combined death and recurrence) in the entire cohort

From: Prognostic utility of systemic inflammatory markers and chronic hepatitis C virus infection status in hepatocellular carcinoma patients treated with local ablation

Variable

Univariate

Multivariate

HR (95% CI)

overall P

P

HR (95% CI)

overall P

P

Treatment

 Microwave ablation

0.99 (0.71–1.37)

 

0.93

   

 Radiofrequency ablation

1.00 (Reference)

     

Age per 10 years

1.07 (0.91–1.26)

 

0.4

   

Gender

      

 Male

1.32 (0.96–1.81)

 

0.09

   

 Female

1.00 (Reference)

     

Cirrhosis

      

 Yes

1.24 (0.73–2.1)

 

0.43

   

 No

1.00 (Reference)

     

Etiology of Liver Disease

 

0.25

    

 HCV (positive HCV RNA)

0.89 (0.45–1.77)

 

0.74

   

 HCV (negative HCV RNA)

0.62 (0.28–1.37)

 

0.23

   

 Non-alcoholic fatty liver

0.99 (0.49–1.98)

 

0.97

   

 Alcoholic Liver disease

0.73 (0.35–1.51)

 

0.39

   

 Others

0.60 (0.3–1.22)

 

0.16

   

 HBV

1.00 (Reference)

     

Child Pugh score

      

 B

1.41 (1.01–1.98)

 

0.043

   

 A

1.00 (Reference)

     

Portal Hypertension

      

 Yes

1.37 (1.004–1.87)

 

0.047

   

 No

1.00 (Reference)

     

Tumor size per 1 unit

1.18 (1.044–1.32)

 

0.008

1.25 (1.043–1.51)

 

0.016

Tumor number per 1 tumor

1.31 (1.11–1.55)

 

0.001

1.29 (1.078–1.53)

 

0.005

BCLC Stage

 

0.004

    

 A

2.27 (1.22–4.25)

 

0.01

   

 B

3.54 (1.68–7.47)

 

< 0.001

   

 0

1.00 (Reference)

     

MELD Score per point

1.03 (0.99–1.072)

 

0.085

1.06 (1.02–1.11)

 

0.002

Hyperlipidemia

 Yes

1.11 (0.79–1.57)

 

0.56

   

 No

1.00 (Reference)

     

Hypothyroidism

 Yes

0.78 (0.53–1.16)

 

0.22

   

 No

1.00 (Reference)

     

Log2 AFP

1.07 (1.005–1.14)

 

0.034

1.11 (1.033–1.2)

 

0.005

Glucose (mg/dl)

1.00 (0.99–1.01)

 

0.11

   

Pre-ablation NLR per unit increase

1.13 (1.035–1.22)

 

0.006

   

Pre-ablation PLR

0.96 (0.73–1.26)

 

0.77

   

Pre-ablation LMR per unit increase

0.83 (0.73–0.95)

 

0.006

0.77 (0.66–0.90)

 

0.001

  1. HCV hepatitis C virus, HBV hepatitis B virus, AFP alpha fetoprotein, NLR neutrophil lymphocyte ratio, PLR platelets lymphocytes ratio, LMR lymphocyte monocyte ratio