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Fig. 3 | BMC Cancer

Fig. 3

From: Digital gene expression analysis of NSCLC-patients reveals strong immune pressure, resulting in an immune escape under immunotherapy

Fig. 3

Mechanism-dependant gene set enrichment analysis (GSEA). The analysis shows the enrichment of differentially expressed genes in association with a certain patient group/escape mechanism within a specific biological process. Blue: Strong pathway enrichment in association with a certain immune escape mechanism, orange: Strong pathway enrichment if the escape mechanism is not present. Stronger colouring hints towards significantly increased/reduced gene enrichment in a specific pathway (FDR, p < 0.05). A Gene set enrichment analysis of patients affected by PD-L1 overexpression. B Gene set enrichment analysis of patients affected by altered epitope processing (discovery cohort). C Gene set enrichment analysis of patients affected by both PD-L1 overexpression and altered epitope processing (combined). D Gene set enrichment analysis of patients affected by altered epitope processing (validation cohort)

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