Inflammation-scores as prognostic markers of overall survival in lung cancer: a register-based study of 6,210 Danish lung cancer patients

Table 3 Inflammation-scores association with overall survival in SCLC

	Cut points	N(%)	Univariate HR (95%CI)	P-value	Adjusted HR (95%CI)	P-value
NLR	< 3	286 (32)	1.00		1.00
	> 3	604 (68)	1.64 (1.41 – 1.90)	< 0.0001	1.35 (1.15 – 1.60)	< 0.0001
	< 4	417 (47)	1.00		1.00
	> 4	473 (53)	1.78 (1.55 – 2.06)	< 0.0001	1.52 (1.30 – 1.77)	< 0.0001
mGPS	0	255 (29)	1.00		1.00
	1	365 (41)	1.36 (1.15 – 1.62)	< 0.0001	1.26 (1.04 – 1.52)	0.017
	2	270 (30)	2.13 (1.77 – 2.55)	< 0.0001	1.67 (1.35 – 2.05)	< 0.0001
PLR	< 150	281 (32)	1.00		1.00
	> 150	609 (68)	1.10 (0.95 – 1.28)	0.211	1.08 (0.92 – 1.27)	0.360
	< 200	457 (51)	1.00		1.00
	> 200	433 (49)	1.22 (1.06 – 1.40)	0.005	1.19 (1.03 – 1.39)	0.021
CNG	0	45 (5)	1.00		1.00
	1	262 (29)	1.90 (1.32 – 2.74)	0.001	1.65 (1.10 – 2.49)	0.018
	2	328 (37)	2.23 (1.56 – 3.20)	< 0.0001	1.88 (1.25 – 2.82)	0.003
	3	255 (29)	3.40 (2.36 – 4.91)	< 0.0001	2.55 (1.68 – 3.87)	< 0.0001
ACBS	0	92 (10)	1.00		1.00
	1	174 (20)	1.50 (1.14 – 1.98)	0.004	1.61 (1.19 – 2.19)	0.002
	2	218 (24)	1.70 (1.30 – 2.22)	< 0.0001	1.45 (1.08 – 1.95)	0.014
	3	406 (46)	2.41 (1.88 – 3.09)	< 0.0001	1.98 (1.50 – 2.62)	< 0.0001
HALP	< 26	864 (97)	1.00		1.00
HALP	> 26	26 (3)	1.07 (0.73 – 1.59)	0.724	1.00 (0.65 – 1.54)	0.983
LMR	< 2.6	508 (57)	1.00		1.00
LMR	> 2.6	382 (43)	0.74 (0.64 – 0.85)	< 0.0001	0.80 (0.69 – 0.93)	0.005
MLR	< 0.367	354 (40)	1.00		1.00
MLR	> 0.367	536 (60)	1.28 (1.11 – 1.47)	0.001	1.23 (1.05 – 1.43)	0.010
SII	< 479	107 (12)	1.00		1.00
SII	> 479	783 (88)	1.10 (0.88 – 1.36)	0.405	1.13 (0.89 – 1.44)	0.326

ACBS Aarhus composite biomarker score, CI confidence interval, CNG The Combined NLR and Glasgow prognostic score, HALP haemoglobin × albumin × lymphocytes/platelet count, HR hazard ratio, LMR lymphocyte to monocyte ratio, mGPS modified Glasgow prognostic score, MLR Monocyte to lymphocyte ratio, NLR Neutrophil to lymphocyte ratio, PLR thrombocyte to lymphocyte ratio, SCLC Small cell lung cancer, SII The systemic inflammation index
P-value calculated by the Log likelihood test

ISSN: 1471-2407