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Table 2 Inflammation-scores association with overall survival in NSCLC

From: Inflammation-scores as prognostic markers of overall survival in lung cancer: a register-based study of 6,210 Danish lung cancer patients

 

Cut points

N(%)

Univariate HR (95%CI)

P-value

Adjusted HR (95%CI)

P-value

NLR

 < 3

1,658 (31)

1.00

 

1.00

 

 > 3

3,662 (69)

2.17 (2.02 – 2.32)

 < 0.0001

1.52 (1.40 – 1.64)

 < 0.0001

 < 4

2,534 (48)

1.00

 

1.00

 

 > 4

2,786 (52)

2.21 (2.07 – 2.35)

 < 0.0001

1.58 (1.47 – 1.69)

 < 0.0001

mGPS

0

1,498 (30)

1.00

 

1.00

 

1

1,883 (36)

2.04 (1.88 – 2.21)

 < 0.0001

1.43 (1.30 – 1.57)

 < 0.0001

2

1,939 (35)

2.95 (2.72 – 3.20)

 < 0.0001

1.70 (1.55 – 1.86)

 < 0.0001

PLR

 < 150

1,571 (30)

1.00

 

1.00

 

 > 150

3,749 (70)

1.61 (1.50 – 1.73)

 < 0.0001

1.25 (1.15 – 1.34)

 < 0.0001

 < 200

2,645 (50)

1.00

 

1.00

 

 > 200

2,675 (50)

1.79 (1.68 – 1.90)

 < 0.0001

1.32 (1.23 – 1.42)

 < 0.0001

CNG

0

329 (5)

1.00

 

1.00

 

1

1,367 (27)

1.46 (1.24 – 1.72)

 < 0.0001

1.25 (1.05 – 1.49)

0.012

2

1,809 (34)

2.86 (2.44 – 3.35)

 < 0.0001

1.74 (1.47 – 2.06)

 < 0.0001

3

1,815 (34)

4.18 (3.57 – 4.89)

 < 0.0001

2.10 (1.77 – 2.49)

 < 0.0001

ACBS

0

666 (13)

1.00

 

1.00

 

1

985 (19)

1.58 (1.39 – 1.80)

 < 0.0001

1.42 (1.24 – 1.64)

 < 0.0001

2

1,067 (20)

2.30 (2.03 – 2.61)

 < 0.0001

1.60 (1.40 – 1.83)

 < 0.0001

3

2,602 (49)

3.97 (3.54 – 4.44)

 < 0.0001

2.24 (1.97 – 2.54)

 < 0.0001

HALP

 < 26

5,209 (98)

1.00

 

1.00

 

 > 26

111 (2)

0.95 (0.78 – 1.17)

0.639

1.28 (1.03 – 1.61)

0.029

LMR

 < 2.6

3,345 (63)

1.00

 

1.00

 

 > 2.6

1,975 (37)

0.57 (0.53 – 0.61)

 < 0.0001

0.78 (0.72 – 0.84)

 < 0.0001

MLR

 < 0.367

1,811 (34)

1.00

 

1.00

 

 > 0.367

3,509 (64)

1.75 (1.63 – 1.87)

 < 0.0001

1.31 (1.21 – 1.41)

 < 0.0001

SII

 < 479

551 (10)

1.00

 

1.00

 

 > 479

4,769 (90)

1.79 (1.61 – 2.00)

 < 0.0001

1.34 (1.19 – 1.51)

 < 0.0001

  1. ACBS Aarhus composite biomarker score, CI confidence interval, CNG The Combined NLR and Glasgow prognostic score, HALP haemoglobin × albumin × lymphocytes/platelet count, HR hazard ratio, LMR lymphocyte to monocyte ratio, mGPS modified Glasgow prognostic score, MLR Monocyte to lymphocyte ratio, NLR Neutrophil to lymphocyte ratio, NSCLC Non-small cell lung cancer, PLR thrombocyte to lymphocyte ratio SII The systemic inflammation index
  2. P-value calculated by the Log likelihood test
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BMC Cancer

ISSN: 1471-2407

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